229166

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1384488..1385176 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag LVJ75_RS06605 Protein ID WP_003406304.1
Coordinates 1384745..1385176 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag LVJ75_RS06600 Protein ID WP_003406302.1
Coordinates 1384488..1384748 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS06580 (LVJ75_06565) 1380065..1380889 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
LVJ75_RS06585 (LVJ75_06570) 1380894..1382075 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
LVJ75_RS06590 (LVJ75_06575) 1382152..1383252 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
LVJ75_RS06595 (LVJ75_06580) 1383423..1384412 + 990 WP_003406301.1 malate dehydrogenase -
LVJ75_RS06600 (LVJ75_06585) 1384488..1384748 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
LVJ75_RS06605 (LVJ75_06590) 1384745..1385176 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ75_RS06610 (LVJ75_06595) 1385199..1386782 - 1584 WP_009940130.1 PE family protein -
LVJ75_RS06615 (LVJ75_06600) 1386962..1387822 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
LVJ75_RS06620 (LVJ75_06605) 1387903..1388733 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
LVJ75_RS06625 (LVJ75_06610) 1388790..1389083 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
LVJ75_RS06630 (LVJ75_06615) 1389080..1389349 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T229166 WP_003406304.1 NZ_CP089780:1384745-1385176 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T229166 NZ_CP124407:73061-73210 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT229166 WP_003406302.1 NZ_CP089780:1384488-1384748 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT229166 NZ_CP124407:c73013-72957 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References