229162

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1013364..1013983 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag LVJ75_RS04800 Protein ID WP_003404726.1
Coordinates 1013549..1013983 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag LVJ75_RS04795 Protein ID WP_003898641.1
Coordinates 1013364..1013543 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS04780 (LVJ75_04770) 1008837..1010417 + 1581 WP_003910977.1 serine hydrolase -
LVJ75_RS04785 (LVJ75_04775) 1010414..1012807 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
LVJ75_RS04790 (LVJ75_04780) 1013080..1013238 + 159 WP_003404720.1 hypothetical protein -
LVJ75_RS04795 (LVJ75_04785) 1013364..1013543 + 180 WP_003898641.1 antitoxin Antitoxin
LVJ75_RS04800 (LVJ75_04790) 1013549..1013983 + 435 WP_003404726.1 SRPBCC family protein Toxin
LVJ75_RS04805 (LVJ75_04795) 1014081..1014854 + 774 WP_003404735.1 VOC family protein -
LVJ75_RS04810 (LVJ75_04800) 1014919..1015368 + 450 WP_003404738.1 hypothetical protein -
LVJ75_RS04815 (LVJ75_04805) 1015503..1015733 - 231 WP_003898642.1 hypothetical protein -
LVJ75_RS04820 (LVJ75_04810) 1015900..1017408 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
LVJ75_RS04825 (LVJ75_04815) 1017410..1018648 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T229162 WP_003404726.1 NZ_CP089780:1013549-1013983 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T229162 NZ_CP124405:c4840368-4840261 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT229162 WP_003898641.1 NZ_CP089780:1013364-1013543 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT229162 NZ_CP124405:4840416-4840482 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References