229154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709214..709839 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag LVJ75_RS03230 Protein ID WP_003403218.1
Coordinates 709438..709839 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag LVJ75_RS03225 Protein ID WP_003403213.1
Coordinates 709214..709441 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS03200 (LVJ75_03195) 704393..704614 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ75_RS03205 (LVJ75_03200) 704756..705361 + 606 WP_003898526.1 hypothetical protein -
LVJ75_RS03210 (LVJ75_03205) 705380..707947 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
LVJ75_RS03215 (LVJ75_03210) 708031..708780 + 750 WP_003898528.1 hypothetical protein -
LVJ75_RS03220 (LVJ75_03215) 708777..709019 + 243 WP_003403210.1 hypothetical protein -
LVJ75_RS03225 (LVJ75_03220) 709214..709441 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
LVJ75_RS03230 (LVJ75_03225) 709438..709839 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
LVJ75_RS03235 (LVJ75_03230) 709968..710051 + 84 Protein_641 galactose-1-phosphate uridylyltransferase -
LVJ75_RS03240 (LVJ75_03235) 710070..711151 + 1082 Protein_642 galactose-1-phosphate uridylyltransferase -
LVJ75_RS03245 (LVJ75_03240) 711148..712239 + 1092 WP_003900977.1 galactokinase -
LVJ75_RS03250 (LVJ75_03245) 712634..713698 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LVJ75_RS03255 (LVJ75_03250) 713802..714749 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T229154 WP_003403218.1 NZ_CP089780:709438-709839 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T229154 NZ_CP124405:3162230-3162403 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT229154 WP_003403213.1 NZ_CP089780:709214-709441 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT229154 NZ_CP124405:3161906-3162202 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References