229152

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 695586..696232 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag LVJ75_RS03125 Protein ID WP_003403137.1
Coordinates 695586..695999 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag LVJ75_RS03130 Protein ID WP_003403139.1
Coordinates 695996..696232 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS03105 (LVJ75_03100) 691669..693219 + 1551 WP_003905349.1 MCE family protein -
LVJ75_RS03110 (LVJ75_03105) 693271..693663 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
LVJ75_RS03115 (LVJ75_03110) 693660..693917 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
LVJ75_RS03120 (LVJ75_03115) 694100..695335 - 1236 WP_003403128.1 ATP-binding protein -
LVJ75_RS03125 (LVJ75_03120) 695586..695999 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ75_RS03130 (LVJ75_03125) 695996..696232 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 Antitoxin
LVJ75_RS03135 (LVJ75_03130) 696336..696842 - 507 WP_003900973.1 two component system sensor kinase HK1 -
LVJ75_RS03140 (LVJ75_03135) 696956..697486 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ75_RS03145 (LVJ75_03140) 697470..698165 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ75_RS03150 (LVJ75_03145) 698288..698599 + 312 WP_003403164.1 hypothetical protein -
LVJ75_RS03155 (LVJ75_03150) 698671..699621 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ75_RS03160 (LVJ75_03155) 699862..700446 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ75_RS03165 (LVJ75_03160) 700448..701158 + 711 Protein_627 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T229152 WP_003403137.1 NZ_CP089780:c695999-695586 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T229152 NZ_CP124405:c2412760-2412653 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT229152 WP_003403139.1 NZ_CP089780:c696232-695996 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT229152 NZ_CP124405:2412809-2412874 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ88

Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References