Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 693271..693917 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag LVJ75_RS03110 Protein ID WP_003403122.1
Coordinates 693271..693663 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag LVJ75_RS03115 Protein ID WP_003403125.1
Coordinates 693660..693917 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS03095 (LVJ75_03090) 688933..690459 + 1527 WP_003403112.1 virulence factor Mce family protein -
LVJ75_RS03100 (LVJ75_03095) 690522..691664 + 1143 WP_003911253.1 virulence factor Mce family protein -
LVJ75_RS03105 (LVJ75_03100) 691669..693219 + 1551 WP_003905349.1 MCE family protein -
LVJ75_RS03110 (LVJ75_03105) 693271..693663 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
LVJ75_RS03115 (LVJ75_03110) 693660..693917 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
LVJ75_RS03120 (LVJ75_03115) 694100..695335 - 1236 WP_003403128.1 ATP-binding protein -
LVJ75_RS03125 (LVJ75_03120) 695586..695999 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
LVJ75_RS03130 (LVJ75_03125) 695996..696232 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
LVJ75_RS03135 (LVJ75_03130) 696336..696842 - 507 WP_003900973.1 two component system sensor kinase HK1 -
LVJ75_RS03140 (LVJ75_03135) 696956..697486 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ75_RS03145 (LVJ75_03140) 697470..698165 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ75_RS03150 (LVJ75_03145) 698288..698599 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T229151 WP_003403122.1 NZ_CP089780:c693663-693271 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T229151 NZ_CP124405:c2412277-2412170 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT229151 WP_003403125.1 NZ_CP089780:c693917-693660 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT229151 NZ_CP124405:2412334-2412391 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References