Detailed information of TA system TA022915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1794165..1794709
• Replicon: chromosome
• Accession: NC_010814
• Organism: Geobacter lovleyi SZ

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B3EAG1
• Locus tag: GLOV_RS08360
• Protein ID: WP_012469739.1
• Coordinates: 1794434..1794709 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GLOV_RS08355
• Protein ID: WP_012469738.1
• Coordinates: 1794165..1794434 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLOV_RS08335	1789889..1790257	+	369	WP_012469736.1	hypothetical protein	-
GLOV_RS08340	1790319..1790888	-	570	WP_012469737.1	HK97 family phage prohead protease	-
GLOV_RS08345	1791288..1792397	+	1110	WP_012468524.1	IS110 family transposase	-
GLOV_RS08350	1792755..1793837	+	1083	WP_012468104.1	IS5-like element ISGlo5 family transposase	-
GLOV_RS08355	1794165..1794434	+	270	WP_012469738.1	ribbon-helix-helix domain-containing protein	Antitoxin
GLOV_RS08360	1794434..1794709	+	276	WP_012469739.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GLOV_RS08365	1795044..1796423	+	1380	WP_012469740.1	sigma 54-interacting transcriptional regulator	-
GLOV_RS08370	1796611..1797021	+	411	WP_012469741.1	hypothetical protein	-
GLOV_RS19830	1797027..1797257	+	231	WP_167320562.1	DUF5320 domain-containing protein	-
GLOV_RS08375	1797367..1797729	+	363	WP_012469742.1	NifB/NifX family molybdenum-iron cluster-binding protein	-
GLOV_RS08380	1797729..1798610	+	882	WP_012469743.1	ATP-binding protein	-
GLOV_RS08385	1798622..1799485	+	864	WP_153304736.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1792755..1793837	1082

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10821.57 Da
• Isoelectric Point: 9.5877

>T22915 WP_012469739.1 NC_010814:1794434-1794709 [Geobacter lovleyi SZ]
MTIKWTSKALSDLVRLYEFLSVKDKLAAARIVQLLSSAPDRLMDQARIGEKLEEFDPREVRRIVVGRYEMRYEIQESVIS
VLRIWHTREDR

Nucleotide

• Length: 276 bp

>T22915 NC_010814:1794434-1794709 [Geobacter lovleyi SZ]
ATGACAATAAAGTGGACCAGCAAAGCCCTGTCAGATTTGGTACGCCTGTATGAGTTTTTATCTGTAAAAGACAAGTTAGC
TGCTGCTCGTATAGTGCAATTGTTGTCATCCGCACCAGATAGACTTATGGATCAAGCAAGAATAGGTGAAAAGCTCGAAG
AGTTTGACCCGCGCGAAGTCCGACGTATTGTTGTTGGTAGATACGAAATGCGCTATGAAATACAAGAGTCTGTTATTTCA
GTGCTCCGGATCTGGCATACACGAGAAGATCGATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9844.27 Da
• Isoelectric Point: 6.0661

>AT22915 WP_012469738.1 NC_010814:1794165-1794434 [Geobacter lovleyi SZ]
MNTMSTKVLTAHIPIPLAEQVDQIAARLERSRGWIVKQALSAWVGQEEERRRLTLEAMADVDAGHVVNHLDVKAWADSLG
TEAPLPVPH

Nucleotide

• Length: 270 bp

>AT22915 NC_010814:1794165-1794434 [Geobacter lovleyi SZ]
ATGAATACAATGAGCACCAAAGTTCTGACTGCACATATTCCAATCCCGCTTGCAGAGCAGGTTGATCAGATTGCCGCACG
ACTAGAGCGTTCTCGCGGATGGATTGTAAAACAGGCTTTAAGCGCCTGGGTTGGGCAAGAAGAAGAGCGTCGTCGTCTGA
CACTGGAGGCTATGGCAGATGTTGACGCTGGGCACGTTGTTAACCACCTGGATGTCAAAGCCTGGGCTGATAGCCTTGGC
ACCGAAGCGCCACTTCCGGTGCCGCACTAA

Structures

Toxin

• AlphaFold DB: B3EAG1