229147

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 362287..362930 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ75_RS01580 Protein ID WP_003401566.1
Coordinates 362505..362930 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ75_RS01575 Protein ID WP_003401563.1
Coordinates 362287..362508 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS01550 (LVJ75_01550) 357406..358209 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ75_RS01555 (LVJ75_01555) 358219..359616 - 1398 WP_003401544.1 sulfatase -
LVJ75_RS01560 (LVJ75_01560) 359795..361570 + 1776 WP_010886074.1 PE family protein -
LVJ75_RS01565 (LVJ75_01565) 361713..361940 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
LVJ75_RS01570 (LVJ75_01570) 361937..362239 + 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ75_RS01575 (LVJ75_01575) 362287..362508 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ75_RS01580 (LVJ75_01580) 362505..362930 + 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ75_RS01585 (LVJ75_01585) 363066..363698 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
LVJ75_RS01590 (LVJ75_01590) 363695..364603 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ75_RS01595 (LVJ75_01595) 364611..365201 - 591 WP_229298012.1 hypothetical protein -
LVJ75_RS01600 (LVJ75_01600) 365194..365244 - 51 Protein_316 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T229147 WP_003401566.1 NZ_CP089780:362505-362930 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T229147 NZ_CP124405:c1702722-1702315 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT229147 WP_003401563.1 NZ_CP089780:362287-362508 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT229147 NZ_CP124405:c1702969-1702703 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References