229143

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4186768..4187401 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag LVJ74_RS19630 Protein ID WP_003400580.1
Coordinates 4186768..4187169 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag LVJ74_RS19635 Protein ID WP_003400577.1
Coordinates 4187162..4187401 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS19615 (LVJ74_19605) 4182778..4183689 - 912 WP_003899798.1 SDR family NAD(P)-dependent oxidoreductase -
LVJ74_RS19620 (LVJ74_19610) 4183792..4184361 + 570 WP_003400591.1 TetR/AcrR family transcriptional regulator -
LVJ74_RS19625 (LVJ74_19615) 4184479..4186716 + 2238 WP_003899797.1 NADP-dependent isocitrate dehydrogenase -
LVJ74_RS19630 (LVJ74_19620) 4186768..4187169 - 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
LVJ74_RS19635 (LVJ74_19625) 4187162..4187401 - 240 WP_003400577.1 antitoxin VapB1 Antitoxin
LVJ74_RS19640 (LVJ74_19630) 4187468..4190407 - 2940 WP_003907192.1 UPF0182 family protein -
LVJ74_RS19645 (LVJ74_19635) 4190448..4190609 - 162 WP_003899796.1 hypothetical protein -
LVJ74_RS19650 (LVJ74_19640) 4190665..4192104 - 1440 WP_003901784.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T229143 WP_003400580.1 NZ_CP089779:c4187169-4186768 [Mycobacterium tuberculosis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

>T229143 NZ_CP124405:c516932-516830 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT229143 WP_003400577.1 NZ_CP089779:c4187401-4187162 [Mycobacterium tuberculosis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp

>AT229143 NZ_CP124405:516792-517060 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHM7

References