Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3891473..3892116 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ74_RS18390 Protein ID WP_003401566.1
Coordinates 3891473..3891898 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ74_RS18395 Protein ID WP_003401563.1
Coordinates 3891895..3892116 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS18380 (LVJ74_18370) 3889800..3890708 - 909 WP_003900117.1 protochlorophyllide reductase -
LVJ74_RS18385 (LVJ74_18375) 3890705..3891337 - 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ74_RS18390 (LVJ74_18380) 3891473..3891898 - 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ74_RS18395 (LVJ74_18385) 3891895..3892116 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ74_RS18400 (LVJ74_18390) 3892164..3892466 - 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ74_RS18405 (LVJ74_18395) 3892463..3892690 - 228 WP_031658821.1 ribbon-helix-helix protein, CopG family -
LVJ74_RS18410 (LVJ74_18400) 3892833..3894572 - 1740 WP_031658820.1 PE family protein -
LVJ74_RS18415 (LVJ74_18405) 3894751..3896148 + 1398 WP_003401544.1 sulfatase -
LVJ74_RS18420 (LVJ74_18410) 3896158..3896961 + 804 WP_003401540.1 Stf0 family sulphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T229140 WP_003401566.1 NZ_CP089779:c3891898-3891473 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T229140 NZ_CP124401:c78647-78342 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT229140 WP_003401563.1 NZ_CP089779:c3892116-3891895 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT229140 NZ_CP124401:c78867-78649 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References