Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1270711..1271307 Replicon chromosome
Accession NC_010814
Organism Geobacter lovleyi SZ

Toxin (Protein)


Gene name PumA Uniprot ID B3E763
Locus tag GLOV_RS06005 Protein ID WP_012469291.1
Coordinates 1270711..1271001 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GLOV_RS06010 Protein ID WP_012469292.1
Coordinates 1271011..1271307 (+) Length 99 a.a.

Genomic Context

GLOV_RS06005GLOV_RS06010GLOV_RS06015GLOV_RS06020GLOV_RS06025GLOV_RS06030GLOV_RS06035GLOV_RS06040
Location: 1270711..1271001 (291 bp)
Type: Toxin
Protein ID: WP_012469291.1
Location: 1271011..1271307 (297 bp)
Type: Antitoxin
Protein ID: WP_012469292.1
Location: 1271657..1272358 (702 bp)
Type: Others
Protein ID: WP_012469293.1
Location: 1272691..1273116 (426 bp)
Type: Others
Protein ID: WP_012469294.1
Location: 1273113..1273355 (243 bp)
Type: Others
Protein ID: WP_012469295.1
Location: 1273431..1274021 (591 bp)
Type: Others
Protein ID: WP_012469296.1
Location: 1274018..1274770 (753 bp)
Type: Others
Protein ID: WP_153304653.1
Location: 1274831..1275973 (1143 bp)
Type: Others
Protein ID: WP_012469298.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GLOV_RS060051270711..1271001+291WP_012469291.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GLOV_RS060101271011..1271307+297WP_012469292.1putative addiction module antidote proteinAntitoxin
GLOV_RS060151271657..1272358-702WP_012469293.1hypothetical protein-
GLOV_RS060201272691..1273116-426WP_012469294.1PIN domain-containing protein-
GLOV_RS060251273113..1273355-243WP_012469295.1hypothetical protein-
GLOV_RS060301273431..1274021-591WP_012469296.1AMMECR1 domain-containing protein-
GLOV_RS060351274018..1274770-753WP_153304653.1VanW family protein-
GLOV_RS060401274831..1275973-1143WP_012469298.1radical SAM family heme chaperone HemW-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10771.45 Da        Isoelectric Point: 10.4470

>T22914 WP_012469291.1 NC_010814:1270711-1271001 [Geobacter lovleyi SZ]
MIEIRKTEQFANWLDNLRDIQAKARVLVRIERLASGNAGDVKPVGEGISEMRINYGPGYRVYFVQRGSELIILLAGGDKS
NQSRDIKAAIRLAQKL

Download         Length: 291 bp

>T22914 NC_010814:1270711-1271001 [Geobacter lovleyi SZ]
ATGATTGAAATCCGTAAAACTGAACAATTTGCCAACTGGCTTGACAACCTGCGTGATATCCAAGCCAAGGCTCGCGTCTT
GGTCAGGATTGAACGTCTTGCCTCGGGAAATGCCGGCGACGTCAAGCCTGTTGGCGAAGGTATTTCGGAAATGAGAATCA
ACTACGGTCCCGGTTATCGTGTCTATTTTGTCCAACGCGGCAGCGAGTTGATCATCCTGCTGGCTGGTGGTGACAAGAGC
AACCAATCTCGGGATATCAAGGCAGCAATTCGCCTTGCACAGAAATTATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10503.91 Da        Isoelectric Point: 6.2258

>AT22914 WP_012469292.1 NC_010814:1271011-1271307 [Geobacter lovleyi SZ]
MTRTTTSRYDVAEHLRTPEEMAAYLEASLEEANGDAAFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGERVPGFDT
ILKIVSALGLKLHAEAAH

Download         Length: 297 bp

>AT22914 NC_010814:1271011-1271307 [Geobacter lovleyi SZ]
ATGACCAGAACAACTACCAGTCGTTATGATGTTGCCGAGCATCTCCGTACTCCGGAAGAAATGGCAGCCTATCTTGAAGC
TTCCCTTGAAGAGGCCAATGGCGATGCCGCTTTTATTGCCAAGGCCCTCGGTGATATTGCCCGTGCCAAGGGGATGTCGC
AGGTGGCTCGTGATGCCGGTCTTTCCCGTGAAAGTCTTTATAAGGCCCTCTCCGGAGAAAGAGTTCCAGGTTTTGATACA
ATTCTCAAAATTGTTTCGGCTTTGGGACTCAAACTTCACGCTGAAGCTGCCCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB3E763

Antitoxin

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Source
ID
Structure
No matching records found

References