Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3810788..3811799 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag LVJ74_RS18060 Protein ID WP_003401859.1
Coordinates 3811206..3811799 (+) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag LVJ74_RS18055 Protein ID WP_003401860.1
Coordinates 3810788..3811177 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS18030 (LVJ74_18020) 3806636..3807391 + 756 WP_003401865.1 XdhC family protein -
LVJ74_RS18035 (LVJ74_18025) 3807388..3807981 + 594 WP_003401864.1 NTP transferase domain-containing protein -
LVJ74_RS18040 (LVJ74_18030) 3807978..3808874 + 897 WP_003898418.1 MoxR family ATPase -
LVJ74_RS18045 (LVJ74_18035) 3808888..3809490 + 603 WP_003898417.1 SRPBCC family protein -
LVJ74_RS18050 (LVJ74_18040) 3809496..3810707 + 1212 WP_003906353.1 VWA domain-containing protein -
LVJ74_RS18055 (LVJ74_18045) 3810788..3811177 + 390 WP_003401860.1 hypothetical protein Antitoxin
LVJ74_RS18060 (LVJ74_18050) 3811206..3811799 + 594 WP_003401859.1 zeta toxin family protein Toxin
LVJ74_RS18065 (LVJ74_18055) 3811824..3812954 + 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
LVJ74_RS18070 (LVJ74_18060) 3812943..3813626 - 684 WP_003401857.1 VTT domain-containing protein -
LVJ74_RS18075 (LVJ74_18065) 3813722..3814756 + 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
LVJ74_RS18080 (LVJ74_18070) 3814768..3816150 - 1383 WP_003898415.1 magnesium transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T229139 WP_003401859.1 NZ_CP089779:3811206-3811799 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T229139 NZ_CP124401:c49839-49705 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT229139 WP_003401860.1 NZ_CP089779:3810788-3811177 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT229139 NZ_CP124401:49884-49944 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References