Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 3615139..3615815 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag LVJ74_RS17105 Protein ID WP_003898500.1
Coordinates 3615402..3615815 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag LVJ74_RS17100 Protein ID WP_003402915.1
Coordinates 3615139..3615405 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS17085 (LVJ74_17075) 3610573..3611553 - 981 WP_003402923.1 o-succinylbenzoate synthase -
LVJ74_RS17090 (LVJ74_17080) 3611550..3613154 - 1605 WP_003402920.1 amidohydrolase -
LVJ74_RS17095 (LVJ74_17085) 3613232..3614947 + 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
LVJ74_RS17100 (LVJ74_17090) 3615139..3615405 + 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LVJ74_RS17105 (LVJ74_17095) 3615402..3615815 + 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ74_RS17110 (LVJ74_17100) 3616129..3617031 + 903 WP_031658828.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
LVJ74_RS17115 (LVJ74_17105) 3617127..3618011 + 885 WP_003402909.1 SDR family oxidoreductase -
LVJ74_RS17120 (LVJ74_17110) 3618074..3618460 + 387 WP_003402907.1 VOC family protein -
LVJ74_RS17125 (LVJ74_17115) 3618580..3619833 + 1254 WP_003402904.1 inorganic phosphate transporter -
LVJ74_RS17130 (LVJ74_17120) 3619830..3620108 + 279 WP_003402901.1 hypothetical protein -
LVJ74_RS17135 (LVJ74_17125) 3620168..3620470 + 303 WP_003402896.1 DUF3349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T229138 WP_003898500.1 NZ_CP089779:3615402-3615815 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T229138 NZ_CP124400:c4907997-4907890 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT229138 WP_003402915.1 NZ_CP089779:3615139-3615405 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT229138 NZ_CP124400:4908045-4908111 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References