229133

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3544637..3545262 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag LVJ74_RS16750 Protein ID WP_003403218.1
Coordinates 3544637..3545038 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag LVJ74_RS16755 Protein ID WP_003403213.1
Coordinates 3545035..3545262 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS16725 (LVJ74_16715) 3539727..3540674 - 948 WP_003403232.1 DUF732 domain-containing protein -
LVJ74_RS16730 (LVJ74_16720) 3540778..3541842 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LVJ74_RS16735 (LVJ74_16725) 3542237..3543328 - 1092 WP_003906403.1 galactokinase -
LVJ74_RS16740 (LVJ74_16730) 3543325..3544406 - 1082 Protein_3301 galactose-1-phosphate uridylyltransferase -
LVJ74_RS16745 (LVJ74_16735) 3544425..3544508 - 84 Protein_3302 galactose-1-phosphate uridylyltransferase -
LVJ74_RS16750 (LVJ74_16740) 3544637..3545038 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
LVJ74_RS16755 (LVJ74_16745) 3545035..3545262 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
LVJ74_RS16760 (LVJ74_16750) 3545457..3545699 - 243 WP_003403210.1 hypothetical protein -
LVJ74_RS16765 (LVJ74_16755) 3545696..3546445 - 750 WP_003898528.1 hypothetical protein -
LVJ74_RS16770 (LVJ74_16760) 3546529..3549096 + 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
LVJ74_RS16775 (LVJ74_16765) 3549115..3549720 - 606 WP_003898526.1 hypothetical protein -
LVJ74_RS16780 (LVJ74_16770) 3549862..3550083 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T229133 WP_003403218.1 NZ_CP089779:c3545038-3544637 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T229133 NZ_CP124400:3498972-3499259 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT229133 WP_003403213.1 NZ_CP089779:c3545262-3545035 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT229133 NZ_CP124400:3499246-3499548 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References