229130

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3501894..3502527 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag LVJ74_RS16530 Protein ID WP_003403365.1
Coordinates 3502144..3502527 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag LVJ74_RS16525 Protein ID WP_003403368.1
Coordinates 3501894..3502049 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS16495 (LVJ74_16485) 3497011..3499374 - 2364 WP_003898547.1 arylsulfatase AtsD -
LVJ74_RS16500 (LVJ74_16490) 3499488..3499742 + 255 WP_003911263.1 antitoxin VapB7 -
LVJ74_RS16505 (LVJ74_16495) 3499739..3500176 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
LVJ74_RS16510 (LVJ74_16500) 3500286..3500531 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
LVJ74_RS16515 (LVJ74_16505) 3500518..3500826 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
LVJ74_RS16520 (LVJ74_16510) 3501102..3501818 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
LVJ74_RS16525 (LVJ74_16515) 3501894..3502049 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ74_RS16530 (LVJ74_16520) 3502144..3502527 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
LVJ74_RS16535 (LVJ74_16525) 3502915..3503925 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
LVJ74_RS16540 (LVJ74_16530) 3504006..3505511 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
LVJ74_RS16545 (LVJ74_16535) 3505582..3506277 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
LVJ74_RS16550 (LVJ74_16540) 3506270..3506662 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
LVJ74_RS16555 (LVJ74_16545) 3506699..3507235 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T229130 WP_003403365.1 NZ_CP089779:3502144-3502527 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T229130 NZ_CP124400:3236008-3236181 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT229130 WP_003403368.1 NZ_CP089779:3501894-3502049 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT229130 NZ_CP124400:3235684-3235980 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References