Detailed information of TA system TA022913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1183157..1183858
• Replicon: chromosome
• Accession: NC_010814
• Organism: Geobacter lovleyi SZ

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B3E6M8
• Locus tag: GLOV_RS05565
• Protein ID: WP_012469202.1
• Coordinates: 1183493..1183858 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: GLOV_RS05560
• Protein ID: WP_012469201.1
• Coordinates: 1183157..1183486 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLOV_RS05535	1178511..1180760	-	2250	WP_012469196.1	hypothetical protein	-
GLOV_RS05540	1180790..1181383	-	594	WP_012469197.1	hypothetical protein	-
GLOV_RS05545	1181503..1181898	-	396	WP_012469198.1	hypothetical protein	-
GLOV_RS05550	1181895..1182092	-	198	WP_012469199.1	helix-turn-helix domain-containing protein	-
GLOV_RS19155	1182200..1182958	+	759	WP_012469200.1	helix-turn-helix domain-containing protein	-
GLOV_RS05560	1183157..1183486	-	330	WP_012469201.1	helix-turn-helix domain-containing protein	Antitoxin
GLOV_RS05565	1183493..1183858	-	366	WP_012469202.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GLOV_RS05570	1183910..1184464	-	555	WP_012469203.1	recombinase family protein	-
GLOV_RS05575	1184727..1185071	-	345	WP_012469204.1	helix-turn-helix transcriptional regulator	-
GLOV_RS05585	1185368..1186630	-	1263	WP_012469206.1	integrase arm-type DNA-binding domain-containing protein	-
GLOV_RS05600	1187067..1187801	-	735	WP_012469207.1	SPOR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13583.75 Da
• Isoelectric Point: 10.1231

>T22913 WP_012469202.1 NC_010814:c1183858-1183493 [Geobacter lovleyi SZ]
MNNKPTKPLEWIASSLKDLKEMPEDVRRFFGVALFMAQAGGKHPDAKPLKGFSGAGVLEIVEDHDGDTYRAVYTVRFADV
VYVLHVFQKKSKTGIATPQAEIEKIKTRLKMAEELHRGKGR

Nucleotide

• Length: 366 bp

>T22913 NC_010814:c1183858-1183493 [Geobacter lovleyi SZ]
ATGAATAACAAGCCTACAAAACCTCTTGAGTGGATTGCCAGCAGCCTGAAAGACCTAAAAGAAATGCCGGAAGACGTCAG
GCGTTTCTTTGGTGTTGCTCTCTTCATGGCCCAGGCAGGCGGTAAGCATCCCGACGCCAAGCCGCTGAAAGGCTTTTCAG
GTGCTGGTGTACTAGAGATTGTTGAAGATCATGACGGCGATACATACCGGGCTGTCTATACGGTACGCTTTGCGGATGTA
GTCTATGTGTTGCATGTATTTCAGAAGAAATCAAAAACAGGGATTGCCACGCCTCAAGCAGAAATAGAGAAGATCAAGAC
GCGGTTGAAGATGGCTGAAGAGTTGCACCGGGGCAAAGGGAGGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12270.34 Da
• Isoelectric Point: 10.1985

>AT22913 WP_012469201.1 NC_010814:c1183486-1183157 [Geobacter lovleyi SZ]
MKEEIELYHSSGNVFADLELPDAEEMQAKALLSIQIHDIIKRRHLTQAQAAELLGIDQPKVSALIRGRLKGFSMERLFHF
LNLLGRDVQIVIKPKARSRQLGSLRVAAA

Nucleotide

• Length: 330 bp

>AT22913 NC_010814:c1183486-1183157 [Geobacter lovleyi SZ]
ATGAAAGAAGAGATTGAATTATACCACAGCAGCGGTAACGTGTTTGCAGACCTTGAACTACCTGATGCCGAAGAAATGCA
GGCAAAGGCCCTGCTCTCTATCCAGATACATGATATCATCAAAAGGCGGCACCTGACCCAGGCACAGGCAGCAGAATTGC
TGGGAATAGATCAGCCCAAGGTATCAGCCTTAATTCGTGGACGCCTGAAAGGCTTTTCCATGGAACGCCTGTTTCACTTC
CTGAACCTGCTGGGCCGGGATGTCCAGATCGTTATCAAGCCCAAGGCACGTTCACGGCAACTGGGCAGCTTGAGAGTCGC
AGCAGCCTGA

Structures

Toxin

• AlphaFold DB: B3E6M8