22912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2206107..2206702 Replicon chromosome
Accession NC_010805
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name chpB Uniprot ID A0A0H3KX85
Locus tag BMULJ_RS25710 Protein ID WP_012216340.1
Coordinates 2206352..2206702 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0H3KPL3
Locus tag BMULJ_RS25705 Protein ID WP_012216341.1
Coordinates 2206107..2206358 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMULJ_RS25690 2201969..2202940 - 972 WP_012216344.1 LysR family transcriptional regulator -
BMULJ_RS25695 2203082..2204386 + 1305 WP_012216343.1 MFS transporter -
BMULJ_RS25700 2204486..2205979 + 1494 WP_012468058.1 M81 family metallopeptidase -
BMULJ_RS25705 2206107..2206358 + 252 WP_012216341.1 PbsX family transcriptional regulator Antitoxin
BMULJ_RS25710 2206352..2206702 + 351 WP_012216340.1 type II toxin-antitoxin system ChpB family toxin Toxin
BMULJ_RS25715 2206881..2208416 - 1536 WP_012468059.1 multidrug efflux transporter outer membrane subunit OpcM -
BMULJ_RS25720 2208427..2211612 - 3186 WP_006412982.1 multidrug efflux RND transporter permease subunit CeoB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12412.41 Da        Isoelectric Point: 8.8909

>T22912 WP_012216340.1 NC_010805:2206352-2206702 [Burkholderia multivorans ATCC 17616]
MVKRVKFERGDIVRVSPNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMIRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T22912 NC_010805:2206352-2206702 [Burkholderia multivorans ATCC 17616]
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTGAGCCCGAATCCGACTCTCGGTCGTGAGCAGCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCGCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCGCTGGTG
AACATGATTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9035.46 Da        Isoelectric Point: 7.9813

>AT22912 WP_012216341.1 NC_010805:2206107-2206358 [Burkholderia multivorans ATCC 17616]
MELKIQKWGNSAAVRLPSVLLEQIKATVGSSLSADVRPDGVLLTPARRKYSLDELVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT22912 NC_010805:2206107-2206358 [Burkholderia multivorans ATCC 17616]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGTGCGGCGGTTCGCTTGCCCAGCGTTCTGCTCGAACAGATCAAAGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
AGCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGGGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KX85

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KPL3

References