Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 2716102..2717152 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag LVJ74_RS12740 Protein ID WP_003407164.1
Coordinates 2716331..2717152 (-) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag LVJ74_RS12735 Protein ID WP_003407167.1
Coordinates 2716102..2716338 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS12720 (LVJ74_12710) 2712072..2713541 - 1470 WP_003900326.1 cytochrome b5 domain-containing protein -
LVJ74_RS12725 (LVJ74_12715) 2713737..2714522 - 786 WP_003407180.1 lipoprotein LprF -
LVJ74_RS12730 (LVJ74_12720) 2714825..2716030 + 1206 WP_003898846.1 serine hydrolase domain-containing protein -
LVJ74_RS12735 (LVJ74_12725) 2716102..2716338 - 237 WP_003407167.1 hypothetical protein Antitoxin
LVJ74_RS12740 (LVJ74_12730) 2716331..2717152 - 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
LVJ74_RS12745 (LVJ74_12735) 2717373..2717759 + 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
LVJ74_RS12750 (LVJ74_12740) 2717898..2719859 + 1962 WP_003407159.1 sigma-F factor regulator -
LVJ74_RS12755 (LVJ74_12745) 2720150..2720935 + 786 WP_003407157.1 membrane protein -
LVJ74_RS12760 (LVJ74_12750) 2720932..2721594 + 663 WP_003407152.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T229118 WP_003407164.1 NZ_CP089779:c2717152-2716331 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T229118 NZ_CP124400:c516678-516576 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT229118 WP_003407167.1 NZ_CP089779:c2716338-2716102 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT229118 NZ_CP124400:516538-516806 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References