229113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2286980..2287440 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag LVJ74_RS10805 Protein ID WP_003898996.1
Coordinates 2286980..2287228 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag LVJ74_RS10810 Protein ID WP_003408528.1
Coordinates 2287228..2287440 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS10785 (LVJ74_10770) 2283154..2283765 + 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -
LVJ74_RS10790 (LVJ74_10775) 2283755..2284156 + 402 WP_003408538.1 hypothetical protein -
LVJ74_RS10795 (LVJ74_10780) 2284441..2286141 - 1701 WP_003898998.1 serine/threonine protein kinase PknE -
LVJ74_RS10800 (LVJ74_10785) 2286235..2286972 - 738 WP_003898997.1 hypothetical protein -
LVJ74_RS10805 (LVJ74_10790) 2286980..2287228 - 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ74_RS10810 (LVJ74_10795) 2287228..2287440 - 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ74_RS10815 (LVJ74_10800) 2287508..2289190 + 1683 WP_003898994.1 SulP family inorganic anion transporter -
LVJ74_RS10820 (LVJ74_10805) 2289204..2289488 - 285 WP_003408522.1 DUF1876 domain-containing protein -
LVJ74_RS10825 (LVJ74_10810) 2289775..2290962 + 1188 WP_003898992.1 nitrate transporter NarK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T229113 WP_003898996.1 NZ_CP089779:c2287228-2286980 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T229113 NZ_CP124388:c48366-48232 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT229113 WP_003408528.1 NZ_CP089779:c2287440-2287228 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT229113 NZ_CP124388:48411-48471 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References