Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2057346..2057890 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag LVJ74_RS09740 Protein ID WP_003409896.1
Coordinates 2057594..2057890 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag LVJ74_RS09735 Protein ID WP_003409899.1
Coordinates 2057346..2057597 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS09710 (LVJ74_09690) 2053073..2053870 - 798 WP_003899101.1 ABC transporter permease -
LVJ74_RS09715 (LVJ74_09695) 2054769..2055989 + 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
LVJ74_RS09720 (LVJ74_09700) 2056022..2056294 + 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ74_RS09725 (LVJ74_09705) 2056298..2056705 + 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
LVJ74_RS09730 (LVJ74_09710) 2056865..2057359 - 495 WP_003899099.1 hypothetical protein -
LVJ74_RS09735 (LVJ74_09715) 2057346..2057597 + 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LVJ74_RS09740 (LVJ74_09720) 2057594..2057890 + 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ74_RS09745 (LVJ74_09725) 2057939..2058553 + 615 WP_003901296.1 hypothetical protein -
LVJ74_RS09750 (LVJ74_09730) 2058442..2058987 - 546 WP_003409891.1 SecB-like chaperone -
LVJ74_RS09755 (LVJ74_09735) 2058984..2059433 - 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
LVJ74_RS09760 (LVJ74_09740) 2059475..2059852 - 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
LVJ74_RS09765 (LVJ74_09745) 2059827..2060348 + 522 WP_003904745.1 hypothetical protein -
LVJ74_RS09770 (LVJ74_09750) 2060322..2060633 - 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
LVJ74_RS09775 (LVJ74_09755) 2060630..2060845 - 216 WP_003409878.1 antitoxin -
LVJ74_RS09780 (LVJ74_09760) 2061085..2061381 + 297 WP_003409877.1 hypothetical protein -
LVJ74_RS09785 (LVJ74_09765) 2061382..2061573 + 192 WP_003409876.1 hypothetical protein -
LVJ74_RS09790 (LVJ74_09770) 2061594..2062496 + 903 WP_003899097.1 hypothetical protein -
LVJ74_RS09795 (LVJ74_09775) 2062507..2062857 + 351 WP_003899096.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T229110 WP_003409896.1 NZ_CP089779:2057594-2057890 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T229110 NZ_CP124387:c4120006-4119788 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT229110 WP_003409899.1 NZ_CP089779:2057346-2057597 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT229110 NZ_CP124387:c4120406-4120032 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References