Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mbcAT/RES-TIGR02293 |
| Location | 2027933..2028831 | Replicon | chromosome |
| Accession | NZ_CP089779 | ||
| Organism | Mycobacterium tuberculosis strain 01-R1134 | ||
Toxin (Protein)
| Gene name | mbcT | Uniprot ID | P64908 |
| Locus tag | LVJ74_RS09575 | Protein ID | WP_003410001.1 |
| Coordinates | 2028271..2028831 (+) | Length | 187 a.a. |
Antitoxin (Protein)
| Gene name | mbcA | Uniprot ID | P64910 |
| Locus tag | LVJ74_RS09570 | Protein ID | WP_003410003.1 |
| Coordinates | 2027933..2028274 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ74_RS09535 (LVJ74_09515) | 2023586..2023942 | + | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| LVJ74_RS09540 (LVJ74_09520) | 2023995..2024267 | + | 273 | WP_003410017.1 | DUF1490 family protein | - |
| LVJ74_RS09545 (LVJ74_09525) | 2024264..2026579 | + | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| LVJ74_RS09550 (LVJ74_09530) | 2026679..2026927 | + | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | - |
| LVJ74_RS09555 (LVJ74_09535) | 2026921..2027265 | + | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | - |
| LVJ74_RS09560 (LVJ74_09540) | 2027354..2027689 | + | 336 | WP_003410009.1 | dehydrogenase | - |
| LVJ74_RS09565 (LVJ74_09545) | 2027590..2027847 | - | 258 | WP_003410006.1 | hypothetical protein | - |
| LVJ74_RS09570 (LVJ74_09550) | 2027933..2028274 | + | 342 | WP_003410003.1 | DUF2384 domain-containing protein | Antitoxin |
| LVJ74_RS09575 (LVJ74_09555) | 2028271..2028831 | + | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | Toxin |
| LVJ74_RS09580 (LVJ74_09560) | 2029351..2029890 | - | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| LVJ74_RS09585 (LVJ74_09565) | 2030116..2030544 | - | 429 | WP_003409992.1 | cellulose-binding protein | - |
| LVJ74_RS09590 (LVJ74_09570) | 2030960..2031559 | - | 600 | WP_003409989.1 | L-lysine exporter | - |
| LVJ74_RS09595 (LVJ74_09575) | 2031668..2032579 | + | 912 | WP_003409986.1 | ArgP/LysG family DNA-binding transcriptional regulator | - |
| LVJ74_RS09600 (LVJ74_09580) | 2032664..2032894 | - | 231 | WP_003409980.1 | DUF167 domain-containing protein | - |
| LVJ74_RS09605 (LVJ74_09585) | 2033009..2033662 | + | 654 | WP_003409976.1 | cutinase Cfp21 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 187 a.a. Molecular weight: 20248.70 Da Isoelectric Point: 4.5091
>T229108 WP_003410001.1 NZ_CP089779:2028271-2028831 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT
Download Length: 561 bp
>T229108 NZ_CP124387:3667660-3667944 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12488.33 Da Isoelectric Point: 4.8359
>AT229108 WP_003410003.1 NZ_CP089779:2027933-2028274 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV
Download Length: 342 bp
>AT229108 NZ_CP124387:3667424-3667657 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|