229106

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2002899..2003525 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag LVJ74_RS09450 Protein ID WP_003410075.1
Coordinates 2002899..2003297 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag LVJ74_RS09455 Protein ID WP_003911750.1
Coordinates 2003298..2003525 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS09420 (LVJ74_09400) 1998498..1999754 + 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -
LVJ74_RS09425 (LVJ74_09405) 1999882..2000472 - 591 WP_003899131.1 IS110 family transposase -
LVJ74_RS09430 (LVJ74_09410) 2000426..2001046 - 621 WP_003410086.1 IS110 family transposase -
LVJ74_RS09435 (LVJ74_09415) 2001134..2001313 + 180 Protein_1859 hypothetical protein -
LVJ74_RS09440 (LVJ74_09420) 2001750..2002184 - 435 WP_003914358.1 DUF1398 domain-containing protein -
LVJ74_RS09445 (LVJ74_09425) 2002285..2002716 + 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
LVJ74_RS09450 (LVJ74_09430) 2002899..2003297 - 399 WP_003410075.1 PIN domain nuclease Toxin
LVJ74_RS09455 (LVJ74_09435) 2003298..2003525 - 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ74_RS09460 (LVJ74_09440) 2003784..2004953 + 1170 WP_003899126.1 ATP-binding protein -
LVJ74_RS09465 (LVJ74_09445) 2005142..2005486 + 345 WP_003410065.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T229106 WP_003410075.1 NZ_CP089779:c2003297-2002899 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T229106 NZ_CP124387:3475758-3476135 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT229106 WP_003911750.1 NZ_CP089779:c2003525-2003298 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT229106 NZ_CP124387:3475300-3475668 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References