Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1891726..1892421 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ74_RS08965 Protein ID WP_003410811.1
Coordinates 1891987..1892421 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ74_RS08960 Protein ID WP_003410814.1
Coordinates 1891726..1891980 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS08930 (LVJ74_08910) 1887074..1887268 + 195 WP_003411026.1 ubiquitin-like protein Pup -
LVJ74_RS08935 (LVJ74_08915) 1887265..1888140 + 876 WP_003411023.1 proteasome subunit beta -
LVJ74_RS08940 (LVJ74_08920) 1888137..1888883 + 747 WP_003906749.1 proteasome subunit alpha -
LVJ74_RS08945 (LVJ74_08925) 1889423..1890154 - 732 WP_003900467.1 PPE family protein -
LVJ74_RS08950 (LVJ74_08930) 1890210..1890506 - 297 WP_003410820.1 PE family protein -
LVJ74_RS08955 (LVJ74_08935) 1891453..1891710 + 258 WP_003410816.1 hypothetical protein -
LVJ74_RS08960 (LVJ74_08940) 1891726..1891980 + 255 WP_003410814.1 antitoxin Antitoxin
LVJ74_RS08965 (LVJ74_08945) 1891987..1892421 + 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ74_RS08970 (LVJ74_08950) 1892400..1893233 - 834 WP_003899172.1 SWIM zinc finger family protein -
LVJ74_RS08975 (LVJ74_08955) 1893226..1896267 - 3042 WP_003899171.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T229103 WP_003410811.1 NZ_CP089779:1891987-1892421 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T229103 NZ_CP124387:2947574-2947885 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT229103 WP_003410814.1 NZ_CP089779:1891726-1891980 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT229103 NZ_CP124387:2947886-2948176 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References