Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/- |
| Location | 1855144..1855673 | Replicon | chromosome |
| Accession | NZ_CP089779 | ||
| Organism | Mycobacterium tuberculosis strain 01-R1134 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TMR4 |
| Locus tag | LVJ74_RS08760 | Protein ID | WP_003411124.1 |
| Coordinates | 1855356..1855673 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P9WJ74 |
| Locus tag | LVJ74_RS08755 | Protein ID | WP_003411127.1 |
| Coordinates | 1855144..1855359 (+) | Length | 72 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ74_RS08725 (LVJ74_08705) | 1850250..1851026 | + | 777 | WP_003411137.1 | YggS family pyridoxal phosphate-dependent enzyme | - |
| LVJ74_RS08730 (LVJ74_08710) | 1851092..1851748 | + | 657 | WP_003411133.1 | cell division protein SepF | - |
| LVJ74_RS08735 (LVJ74_08715) | 1851910..1852200 | + | 291 | WP_003900476.1 | YggT family protein | - |
| LVJ74_RS08740 (LVJ74_08720) | 1852468..1853250 | + | 783 | WP_003411131.1 | cell wall synthesis protein Wag31 | - |
| LVJ74_RS08745 (LVJ74_08725) | 1853345..1853701 | + | 357 | WP_003411130.1 | hypothetical protein | - |
| LVJ74_RS08750 (LVJ74_08730) | 1853831..1854889 | - | 1059 | WP_003411129.1 | phosphoribosyltransferase family protein | - |
| LVJ74_RS08755 (LVJ74_08735) | 1855144..1855359 | + | 216 | WP_003411127.1 | antitoxin ParD2 | Antitoxin |
| LVJ74_RS08760 (LVJ74_08740) | 1855356..1855673 | + | 318 | WP_003411124.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LVJ74_RS08770 (LVJ74_08750) | 1856144..1857490 | + | 1347 | WP_003411121.1 | M20/M25/M40 family metallo-hydrolase | - |
| LVJ74_RS08775 (LVJ74_08755) | 1857538..1858068 | + | 531 | WP_003411119.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
| LVJ74_RS08780 (LVJ74_08760) | 1858073..1859146 | - | 1074 | WP_003411116.1 | quinone-dependent dihydroorotate dehydrogenase | - |
| LVJ74_RS08785 (LVJ74_08765) | 1859182..1859463 | - | 282 | WP_003411112.1 | DUF5703 family protein | - |
| LVJ74_RS08790 (LVJ74_08770) | 1859460..1860536 | - | 1077 | WP_003411110.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12312.88 Da Isoelectric Point: 6.4831
>T229102 WP_003411124.1 NZ_CP089779:1855356-1855673 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
Download Length: 318 bp
>T229102 NZ_CP124387:2691806-2692183 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTTCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATGACATTAGCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTTCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATGACATTAGCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 72 a.a. Molecular weight: 7880.70 Da Isoelectric Point: 4.4055
>AT229102 WP_003411127.1 NZ_CP089779:1855144-1855359 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
Download Length: 216 bp
>AT229102 NZ_CP124387:2691349-2691717 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TMR4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4FAJ4 |