Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1454097..1454749 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag LVJ74_RS06860 Protein ID WP_003412752.1
Coordinates 1454097..1454522 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag LVJ74_RS06865 Protein ID WP_003412749.1
Coordinates 1454528..1454749 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS06835 (LVJ74_06825) 1449102..1449659 + 558 WP_003412768.1 MaoC family dehydratase -
LVJ74_RS06840 (LVJ74_06830) 1449656..1450477 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
LVJ74_RS06845 (LVJ74_06835) 1450736..1451839 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
LVJ74_RS06850 (LVJ74_06840) 1451850..1452896 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
LVJ74_RS06855 (LVJ74_06845) 1452893..1454074 + 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
LVJ74_RS06860 (LVJ74_06850) 1454097..1454522 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ74_RS06865 (LVJ74_06855) 1454528..1454749 - 222 WP_003412749.1 antitoxin Antitoxin
LVJ74_RS06870 (LVJ74_06860) 1454802..1455554 - 753 WP_003900859.1 hypothetical protein -
LVJ74_RS06875 (LVJ74_06865) 1455544..1456167 - 624 WP_003900858.1 TIGR00725 family protein -
LVJ74_RS06880 (LVJ74_06870) 1456303..1456509 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T229101 WP_003412752.1 NZ_CP089779:c1454522-1454097 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T229101 NZ_CP124387:c2496214-2496107 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT229101 WP_003412749.1 NZ_CP089779:c1454749-1454528 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT229101 NZ_CP124387:2496263-2496328 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References