229100

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1407925..1408565 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag LVJ74_RS06665 Protein ID WP_003412970.1
Coordinates 1408146..1408565 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag LVJ74_RS06660 Protein ID WP_003412975.1
Coordinates 1407925..1408149 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS06640 (LVJ74_06630) 1403542..1404105 + 564 WP_003412989.1 elongation factor P -
LVJ74_RS06645 (LVJ74_06635) 1404108..1404578 + 471 WP_003899364.1 transcription antitermination factor NusB -
LVJ74_RS06650 (LVJ74_06640) 1404578..1404979 + 402 WP_003412981.1 hypothetical protein -
LVJ74_RS06655 (LVJ74_06645) 1405051..1407894 + 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
LVJ74_RS06660 (LVJ74_06650) 1407925..1408149 + 225 WP_003412975.1 antitoxin VapB39 Antitoxin
LVJ74_RS06665 (LVJ74_06655) 1408146..1408565 + 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ74_RS06670 (LVJ74_06660) 1408566..1409516 - 951 WP_003911916.1 ERCC4 domain-containing protein -
LVJ74_RS06675 (LVJ74_06665) 1409575..1409820 + 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LVJ74_RS06680 (LVJ74_06670) 1410161..1411081 + 921 WP_003412965.1 restriction endonuclease -
LVJ74_RS06685 (LVJ74_06675) 1411116..1411517 - 402 WP_003412963.1 PIN domain-containing protein -
LVJ74_RS06690 (LVJ74_06680) 1411514..1411741 - 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
LVJ74_RS06695 (LVJ74_06685) 1412258..1412980 + 723 WP_003412957.1 DUF1906 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T229100 WP_003412970.1 NZ_CP089779:1408146-1408565 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T229100 NZ_CP124387:c2495731-2495624 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT229100 WP_003412975.1 NZ_CP089779:1407925-1408149 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT229100 NZ_CP124387:2495788-2495845 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References