Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1696291..1696982 Replicon chromosome
Accession NC_010805
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H3KND5
Locus tag BMULJ_RS23565 Protein ID WP_012216645.1
Coordinates 1696291..1696746 (-) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132F1C7
Locus tag BMULJ_RS23570 Protein ID WP_012216644.1
Coordinates 1696743..1696982 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMULJ_RS23545 1692647..1693597 + 951 WP_080512386.1 DMT family transporter -
BMULJ_RS23550 1693862..1694437 + 576 WP_012216647.1 hypothetical protein -
BMULJ_RS23555 1694531..1694665 - 135 WP_006396654.1 entericidin A/B family lipoprotein -
BMULJ_RS23560 1694898..1696193 + 1296 WP_012216646.1 aspartate carbamoyltransferase -
BMULJ_RS23565 1696291..1696746 - 456 WP_012216645.1 type II toxin-antitoxin system VapC family toxin Toxin
BMULJ_RS23570 1696743..1696982 - 240 WP_012216644.1 Arc family DNA-binding protein Antitoxin
BMULJ_RS23575 1697287..1699533 + 2247 WP_012216643.1 TonB-dependent siderophore receptor -
BMULJ_RS23580 1699537..1700292 + 756 WP_012216642.1 sel1 repeat family protein -
BMULJ_RS23585 1700289..1700972 + 684 WP_012216641.1 Fe2+-dependent dioxygenase -
BMULJ_RS23590 1701376..1701615 + 240 WP_006416205.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16209.65 Da        Isoelectric Point: 9.8210

>T22910 WP_012216645.1 NC_010805:c1696746-1696291 [Burkholderia multivorans ATCC 17616]
MILVDTNVISEPLRRKPSAAVIEWLDAQNVETLFLAAISLAEMRFAVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGTAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T22910 NC_010805:c1696746-1696291 [Burkholderia multivorans ATCC 17616]
ATGATCCTTGTTGATACGAACGTCATTTCCGAACCGCTGCGGCGCAAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
ACAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGCTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTGGCGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGAGCAAGGCCTATGCACGCATTCGCGCGCACGCCCGTGCCGGCGGCACCGCGATCGCGCCCGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGACCCGTGGGCGTCGCAGGGCGCGCCGGTGCGCCAAGGTATCGCGTCGAAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8716.94 Da        Isoelectric Point: 5.1133

>AT22910 WP_012216644.1 NC_010805:c1696982-1696743 [Burkholderia multivorans ATCC 17616]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT22910 NC_010805:c1696982-1696743 [Burkholderia multivorans ATCC 17616]
ATGCCGGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTGGGAACCTTGCTGGCGG
AAATCGGACGGGAGGCAGGCGGTGTCGATCTCGACATTCAGCGTGACAAGACGCCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KND5

Antitoxin

Source ID Structure
AlphaFold DB A0A132F1C7

References