Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 1128400..1130174 | Replicon | chromosome |
| Accession | NZ_CP089779 | ||
| Organism | Mycobacterium tuberculosis strain 01-R1134 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | LVJ74_RS05120 | Protein ID | WP_003414409.1 |
| Coordinates | 1129290..1130174 (+) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | LVJ74_RS05115 | Protein ID | WP_003414414.1 |
| Coordinates | 1128400..1129287 (+) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ74_RS05085 (LVJ74_05070) | 1124702..1125784 | + | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
| LVJ74_RS05090 (LVJ74_05075) | 1125863..1126612 | - | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| LVJ74_RS05095 (LVJ74_05080) | 1126659..1126874 | + | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ74_RS05100 (LVJ74_05085) | 1126871..1127263 | + | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ74_RS05105 (LVJ74_05090) | 1127284..1127553 | + | 270 | WP_003414489.1 | DUF2277 family protein | - |
| LVJ74_RS05110 (LVJ74_05095) | 1127550..1128095 | + | 546 | WP_003899500.1 | DUF1802 family protein | - |
| LVJ74_RS05115 (LVJ74_05100) | 1128400..1129287 | + | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| LVJ74_RS05120 (LVJ74_05105) | 1129290..1130174 | + | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LVJ74_RS05125 (LVJ74_05110) | 1130446..1130991 | + | 546 | WP_003913758.1 | DUF1802 family protein | - |
| LVJ74_RS05130 (LVJ74_05115) | 1131325..1132113 | + | 789 | WP_176747983.1 | CRISPR-associated endoribonuclease Cas6 | - |
| LVJ74_RS05135 (LVJ74_05120) | 1132110..1134548 | + | 2439 | WP_031658945.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| LVJ74_RS05140 (LVJ74_05125) | 1134545..1134919 | + | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T229091 WP_003414409.1 NZ_CP089779:1129290-1130174 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T229091 NZ_CP124387:c517631-517529 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT229091 WP_003414414.1 NZ_CP089779:1128400-1129287 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT229091 NZ_CP124387:517491-517759 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|