Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1513003..1514750 Replicon chromosome
Accession NC_010805
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name doc Uniprot ID A0A0H3KM73
Locus tag BMULJ_RS22615 Protein ID WP_012216806.1
Coordinates 1513854..1514750 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID J5C5E7
Locus tag BMULJ_RS22610 Protein ID WP_006413828.1
Coordinates 1513003..1513857 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMULJ_RS22590 1508158..1509648 - 1491 WP_012216810.1 aldehyde dehydrogenase -
BMULJ_RS22595 1509726..1510556 - 831 WP_012216809.1 aspartate dehydrogenase -
BMULJ_RS22600 1510549..1512216 - 1668 WP_012216808.1 thiamine pyrophosphate-binding protein -
BMULJ_RS22605 1512209..1513006 - 798 WP_012216807.1 SDR family oxidoreductase -
BMULJ_RS22610 1513003..1513857 - 855 WP_006413828.1 IclR family transcriptional regulator Antitoxin
BMULJ_RS22615 1513854..1514750 - 897 WP_012216806.1 alpha/beta fold hydrolase Toxin
BMULJ_RS22620 1514769..1515296 - 528 WP_006396778.1 cupin domain-containing protein -
BMULJ_RS22625 1515324..1516094 - 771 WP_012216805.1 SDR family oxidoreductase -
BMULJ_RS22630 1516087..1517157 - 1071 WP_006413805.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BMULJ_RS22635 1517205..1517516 - 312 WP_012216804.1 hypothetical protein -
BMULJ_RS22640 1517518..1517835 - 318 WP_006396774.1 non-heme iron oxygenase ferredoxin subunit -
BMULJ_RS22645 1518271..1519350 + 1080 WP_006413812.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30611.89 Da        Isoelectric Point: 8.0534

>T22909 WP_012216806.1 NC_010805:c1514750-1513854 [Burkholderia multivorans ATCC 17616]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAVAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDLERRAA

Download         Length: 897 bp

>T22909 NC_010805:c1514750-1513854 [Burkholderia multivorans ATCC 17616]
ATGAGTGTCGTCGACAAACGAGAACGCGACCGCACCGCGGCGTTCGCCACGCTGCTCGAGCGGTTTCCCGAGCAGCGCTG
CGCCGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGTGCGCAGCATGCCGGCGCCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCTTCGCGCCGCGTGCTCGCGTGG
GACGCGCCCGGCTACGGCGCATCGACGCCGGTGCACGGCGCATCGCCGTCGGCCGTCGATTACGCGGCGTCGCTCGACGC
GTGGCTCGATGCGCTCGGCATCGCGCGCTGCGTGCTCGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGC
GCGTGAAGCCCGAGCGAATCGCGGGGCTGCTGCTGATTTCGCCGGCCGGCGGTTACGGCAGCGCGCCGGCGGAGACGCGC
GCGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGGCCTGCCGGGCTCGCCGCGCAGCGCAGCGGCAACAT
GCTGTCGGGCTTCGCGACCGAAGACGCGCGCGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCCAATGCCGATCTCGCCGCCGATCTCGCCGGGTTTCGCGGCCGCACGGCGGTGGCCGTCGGC
GCGAACGACGCGATTACGCCGCCCGCGGCGTGCGAGCGCATCGCGGCGGTCGCCGGCGTCGGACTGCAGGTGATTCCGCA
GGCCGGCCACGCGGGCTACGTCGAGGCGCCGGACGTCTATTCGGCCTTGATCGACACGTTCTGCCGGCAGTGCGACCTCG
AGCGGAGGGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.74 Da        Isoelectric Point: 6.9856

>AT22909 WP_006413828.1 NC_010805:c1513857-1513003 [Burkholderia multivorans ATCC 17616]
MSEPLQSAAEPAKTEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDALRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT22909 NC_010805:c1513857-1513003 [Burkholderia multivorans ATCC 17616]
ATGAGCGAACCGTTGCAGAGCGCGGCCGAGCCCGCGAAGACCGAAGCGAGCTACGTCGTGCCGGGCCTCGAGCGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAACCGGTACTCGGTGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACCGTATTCCGTCTGCTGCAGACGCTCGAATCTCTGGGCTTTCTCGAGCGCGCCGACAAGGACCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGGCTCGGCTTCGAATATCTGAGCTCGCTCGAGCTGACCGATCTCGGCCTGCCCGTGATCGAAAG
CCTGCGCGATGCGACGGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
GCGAGGCGCCCGTGTTCAGTTCGATTCGCGTGAACGTCGGTACGCGGCTGCCCGCGCACGCGACGACGCACGGTCACGTG
CTGATGGGCGACCTCTCGCTGGACGCGCTGCGCGCGCTGTATCCGGAAGGCACGCTGCCGCGGATGACGAACGCGACGCC
GGACACGGTCGACGCGCTGTACACCATGATCCGCGAGGATGCGCTGCGCGGATACGGCATCAGCAATTCGTCGTTCGAGC
GCGGGATTTCGGTCGTCACCGCGCCGGTACGCAACGACACGCAGAAGATCGTCGCCTGCATCACGGTGACGGTGCCGCGC
CCGGAGATCGACGCGACGCTGATCGCCGACGGGCTGATCGACAAGGTGCGGCGCGCGGCGGCCGAACTGTCGCGGCGGCT
CAATTACCGCTCGGACGACGAGCACACGTTTTTGAAGGCTTTGGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KM73

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KMB1

References