Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1085852..1086400 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag LVJ74_RS04900 Protein ID WP_003414602.1
Coordinates 1085852..1086115 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag LVJ74_RS04905 Protein ID WP_003414599.1
Coordinates 1086119..1086400 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS04880 (LVJ74_04870) 1080926..1082167 + 1242 WP_031658947.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
LVJ74_RS04885 (LVJ74_04875) 1082175..1083389 + 1215 WP_003899518.1 zinc metalloprotease Rip -
LVJ74_RS04890 (LVJ74_04880) 1083406..1084569 + 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
LVJ74_RS04895 (LVJ74_04885) 1084625..1085479 + 855 WP_003899516.1 GNAT family N-acetyltransferase -
LVJ74_RS04900 (LVJ74_04890) 1085852..1086115 - 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ74_RS04905 (LVJ74_04895) 1086119..1086400 - 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
LVJ74_RS04910 (LVJ74_04900) 1086672..1088483 + 1812 WP_003414596.1 penicillin-binding protein -
LVJ74_RS04915 (LVJ74_04905) 1088565..1088945 - 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
LVJ74_RS04920 (LVJ74_04910) 1088942..1089190 - 249 WP_003913411.1 antitoxin VapB23 -
LVJ74_RS04925 (LVJ74_04915) 1089294..1089878 + 585 WP_003899514.1 DUF1707 domain-containing protein -
LVJ74_RS04930 (LVJ74_04920) 1089920..1090777 + 858 WP_003899513.1 type I methionyl aminopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T229089 WP_003414602.1 NZ_CP089779:c1086115-1085852 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T229089 NZ_CP124386:98782-99198 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT229089 WP_003414599.1 NZ_CP089779:c1086400-1086119 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT229089 NZ_CP124386:98555-98785 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References