229086

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 555872..556546 Replicon chromosome
Accession NZ_CP089779
Organism Mycobacterium tuberculosis strain 01-R1134

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ74_RS02500 Protein ID WP_003417282.1
Coordinates 556118..556546 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ74_RS02495 Protein ID WP_003417286.1
Coordinates 555872..556114 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ74_RS02470 (LVJ74_02455) 552336..553472 + 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -
LVJ74_RS02475 (LVJ74_02460) 553569..553943 + 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LVJ74_RS02480 (LVJ74_02465) 553940..554473 + 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ74_RS02485 (LVJ74_02470) 554474..555139 + 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LVJ74_RS02490 (LVJ74_02475) 555136..555750 + 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ74_RS02495 (LVJ74_02480) 555872..556114 + 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ74_RS02500 (LVJ74_02485) 556118..556546 + 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ74_RS02505 (LVJ74_02490) 556625..557416 - 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ74_RS02510 (LVJ74_02495) 557416..559188 - 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ74_RS02515 (LVJ74_02500) 559317..559751 - 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ74_RS02520 (LVJ74_02505) 559748..560086 - 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ74_RS02525 (LVJ74_02510) 560323..560724 + 402 WP_003417264.1 cytidine deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T229086 WP_003417282.1 NZ_CP089779:556118-556546 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T229086 NZ_CP124385:c5210927-5210820 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT229086 WP_003417286.1 NZ_CP089779:555872-556114 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT229086 NZ_CP124385:5210975-5211041 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References