Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3782858..3783387 | Replicon | chromosome |
| Accession | NZ_CP089778 | ||
| Organism | Mycobacterium tuberculosis strain I0003758-5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | LVJ73_RS17795 | Protein ID | WP_003417760.1 |
| Coordinates | 3783130..3783387 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | LVJ73_RS17790 | Protein ID | WP_003417757.1 |
| Coordinates | 3782858..3783133 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ73_RS17755 (LVJ73_17760) | 3779431..3780120 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| LVJ73_RS17760 (LVJ73_17765) | 3780307..3780678 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| LVJ73_RS17765 (LVJ73_17770) | 3780576..3780794 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| LVJ73_RS17770 (LVJ73_17775) | 3780821..3781081 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| LVJ73_RS17775 (LVJ73_17780) | 3781196..3781585 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| LVJ73_RS17780 (LVJ73_17785) | 3781599..3781892 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| LVJ73_RS17785 (LVJ73_17790) | 3781889..3782734 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| LVJ73_RS17790 (LVJ73_17795) | 3782858..3783133 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| LVJ73_RS17795 (LVJ73_17800) | 3783130..3783387 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| LVJ73_RS17800 (LVJ73_17805) | 3783429..3784619 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| LVJ73_RS17805 (LVJ73_17810) | 3784736..3785104 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| LVJ73_RS17810 (LVJ73_17815) | 3785101..3785652 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| LVJ73_RS17815 (LVJ73_17820) | 3785659..3786240 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| LVJ73_RS17820 (LVJ73_17825) | 3786221..3786589 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| LVJ73_RS17825 (LVJ73_17830) | 3786567..3786959 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T229080 WP_003417760.1 NZ_CP089778:3783130-3783387 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T229080 NZ_CP089778:3783130-3783387 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT229080 WP_003417757.1 NZ_CP089778:3782858-3783133 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT229080 NZ_CP089778:3782858-3783133 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|