Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1208876..1209410 Replicon chromosome
Accession NC_010805
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name parE Uniprot ID J4RBB5
Locus tag BMULJ_RS21380 Protein ID WP_006413674.1
Coordinates 1209111..1209410 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J4RB90
Locus tag BMULJ_RS21375 Protein ID WP_006413656.1
Coordinates 1208876..1209121 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMULJ_RS21360 1203930..1205633 + 1704 WP_012216994.1 VRR-NUC domain-containing protein -
BMULJ_RS21365 1205630..1207930 + 2301 WP_012467925.1 ATP-dependent DNA helicase -
BMULJ_RS21370 1207967..1208737 - 771 WP_006403543.1 helix-turn-helix domain-containing protein -
BMULJ_RS21375 1208876..1209121 + 246 WP_006413656.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BMULJ_RS21380 1209111..1209410 + 300 WP_006413674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMULJ_RS21385 1209519..1210820 - 1302 WP_006403538.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
BMULJ_RS21390 1210991..1211719 + 729 WP_012216991.1 HNH endonuclease -
BMULJ_RS21395 1211754..1213061 - 1308 WP_012216990.1 shikimate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11542.08 Da        Isoelectric Point: 8.4461

>T22908 WP_006413674.1 NC_010805:1209111-1209410 [Burkholderia multivorans ATCC 17616]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLGQAERYIGELSTAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T22908 NC_010805:1209111-1209410 [Burkholderia multivorans ATCC 17616]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCACTGGCGGAGGCCGATCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCACTCGGCCAGGCTGAGCGCTATATCGGCGAGCTGAGCACGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGTCGCGCGGGCGGCAACTATTCGCGCTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8632.71 Da        Isoelectric Point: 6.4604

>AT22908 WP_006413656.1 NC_010805:1208876-1209121 [Burkholderia multivorans ATCC 17616]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT22908 NC_010805:1208876-1209121 [Burkholderia multivorans ATCC 17616]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTACGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCCCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KLL7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KUX0

References