Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 1208876..1209410 | Replicon | chromosome |
Accession | NC_010805 | ||
Organism | Burkholderia multivorans ATCC 17616 |
Toxin (Protein)
Gene name | parE | Uniprot ID | J4RBB5 |
Locus tag | BMULJ_RS21380 | Protein ID | WP_006413674.1 |
Coordinates | 1209111..1209410 (+) | Length | 100 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | J4RB90 |
Locus tag | BMULJ_RS21375 | Protein ID | WP_006413656.1 |
Coordinates | 1208876..1209121 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BMULJ_RS21360 | 1203930..1205633 | + | 1704 | WP_012216994.1 | VRR-NUC domain-containing protein | - |
BMULJ_RS21365 | 1205630..1207930 | + | 2301 | WP_012467925.1 | ATP-dependent DNA helicase | - |
BMULJ_RS21370 | 1207967..1208737 | - | 771 | WP_006403543.1 | helix-turn-helix domain-containing protein | - |
BMULJ_RS21375 | 1208876..1209121 | + | 246 | WP_006413656.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
BMULJ_RS21380 | 1209111..1209410 | + | 300 | WP_006413674.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BMULJ_RS21385 | 1209519..1210820 | - | 1302 | WP_006403538.1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | - |
BMULJ_RS21390 | 1210991..1211719 | + | 729 | WP_012216991.1 | HNH endonuclease | - |
BMULJ_RS21395 | 1211754..1213061 | - | 1308 | WP_012216990.1 | shikimate transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11542.08 Da Isoelectric Point: 8.4461
>T22908 WP_006413674.1 NC_010805:1209111-1209410 [Burkholderia multivorans ATCC 17616]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLGQAERYIGELSTAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL
MPVKARTVRLTPLAEADLEAIWAYTYERWSLGQAERYIGELSTAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL
Download Length: 300 bp
>T22908 NC_010805:1209111-1209410 [Burkholderia multivorans ATCC 17616]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCACTGGCGGAGGCCGATCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCACTCGGCCAGGCTGAGCGCTATATCGGCGAGCTGAGCACGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGTCGCGCGGGCGGCAACTATTCGCGCTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCACTGGCGGAGGCCGATCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCACTCGGCCAGGCTGAGCGCTATATCGGCGAGCTGAGCACGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGTCGCGCGGGCGGCAACTATTCGCGCTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8632.71 Da Isoelectric Point: 6.4604
>AT22908 WP_006413656.1 NC_010805:1208876-1209121 [Burkholderia multivorans ATCC 17616]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G
Download Length: 246 bp
>AT22908 NC_010805:1208876-1209121 [Burkholderia multivorans ATCC 17616]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTACGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCCCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTACGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCCCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3KLL7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3KUX0 |