Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 393196..393816 Replicon chromosome
Accession NC_010805
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag BMULJ_RS17825 Protein ID WP_012217495.1
Coordinates 393499..393816 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag BMULJ_RS17820 Protein ID WP_006398012.1
Coordinates 393196..393495 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMULJ_RS17795 388431..389699 + 1269 WP_012467811.1 Rieske 2Fe-2S domain-containing protein -
BMULJ_RS17800 389714..390202 + 489 WP_006398008.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
BMULJ_RS17805 390220..390546 + 327 WP_006404219.1 non-heme iron oxygenase ferredoxin subunit -
BMULJ_RS17810 390536..391756 + 1221 WP_012217497.1 FAD-dependent oxidoreductase -
BMULJ_RS17815 391870..393156 + 1287 WP_012217496.1 DUF445 domain-containing protein -
BMULJ_RS17820 393196..393495 - 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
BMULJ_RS17825 393499..393816 - 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMULJ_RS17830 394179..395819 + 1641 WP_006398015.1 acetolactate synthase large subunit -
BMULJ_RS17835 395848..397281 + 1434 WP_012217494.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T22907 WP_012217495.1 NC_010805:c393816-393499 [Burkholderia multivorans ATCC 17616]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T22907 NC_010805:c393816-393499 [Burkholderia multivorans ATCC 17616]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT22907 WP_006398012.1 NC_010805:c393495-393196 [Burkholderia multivorans ATCC 17616]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT22907 NC_010805:c393495-393196 [Burkholderia multivorans ATCC 17616]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
CTGCCTGCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References