Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2819254..2819906 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name vapC Uniprot ID Q7D717
Locus tag LVJ73_RS13230 Protein ID WP_003900860.1
Coordinates 2819481..2819906 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag LVJ73_RS13225 Protein ID WP_003412749.1
Coordinates 2819254..2819475 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS13210 (LVJ73_13215) 2817494..2817700 - 207 WP_003899347.1 hypothetical protein -
LVJ73_RS13215 (LVJ73_13220) 2817836..2818459 + 624 WP_003900858.1 TIGR00725 family protein -
LVJ73_RS13220 (LVJ73_13225) 2818449..2819201 + 753 WP_053868403.1 hypothetical protein -
LVJ73_RS13225 (LVJ73_13230) 2819254..2819475 + 222 WP_003412749.1 antitoxin Antitoxin
LVJ73_RS13230 (LVJ73_13235) 2819481..2819906 + 426 WP_003900860.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ73_RS13235 (LVJ73_13240) 2819929..2821110 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
LVJ73_RS13240 (LVJ73_13245) 2821107..2822153 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
LVJ73_RS13245 (LVJ73_13250) 2822164..2823267 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
LVJ73_RS13250 (LVJ73_13255) 2823526..2824347 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
LVJ73_RS13255 (LVJ73_13260) 2824344..2824901 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-139)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15333.82 Da        Isoelectric Point: 8.1220

>T229065 WP_003900860.1 NZ_CP089778:2819481-2819906 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARPVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T229065 NZ_CP124385:c515046-514944 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT229065 WP_003412749.1 NZ_CP089778:2819254-2819475 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT229065 NZ_CP124385:514906-515174 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7ZFR7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References