Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2379292..2379987 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ73_RS11100 Protein ID WP_003410811.1
Coordinates 2379292..2379726 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ73_RS11105 Protein ID WP_003410814.1
Coordinates 2379733..2379987 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS11090 (LVJ73_11105) 2375446..2378487 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
LVJ73_RS11095 (LVJ73_11110) 2378480..2379313 + 834 WP_003899172.1 SWIM zinc finger family protein -
LVJ73_RS11100 (LVJ73_11115) 2379292..2379726 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ73_RS11105 (LVJ73_11120) 2379733..2379987 - 255 WP_003410814.1 antitoxin Antitoxin
LVJ73_RS11110 (LVJ73_11125) 2380003..2380260 - 258 WP_003410816.1 hypothetical protein -
LVJ73_RS11115 (LVJ73_11130) 2381207..2381503 + 297 WP_003410820.1 PE family protein -
LVJ73_RS11120 (LVJ73_11135) 2381559..2382290 + 732 WP_003900467.1 PPE family protein -
LVJ73_RS11125 (LVJ73_11140) 2382830..2383576 - 747 WP_003899174.1 proteasome subunit alpha -
LVJ73_RS11130 (LVJ73_11145) 2383573..2384448 - 876 WP_003411023.1 proteasome subunit beta -
LVJ73_RS11135 (LVJ73_11150) 2384445..2384639 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T229063 WP_003410811.1 NZ_CP089778:c2379726-2379292 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T229063 NZ_CP124377:2042-2320 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT229063 WP_003410814.1 NZ_CP089778:c2379987-2379733 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT229063 NZ_CP124377:1773-2042 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCACGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References