22906

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 3371106..3371743 Replicon chromosome
Accession NC_010804
Organism Burkholderia multivorans ATCC 17616

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H3KIE2
Locus tag BMULJ_RS15630 Protein ID WP_012212496.1
Coordinates 3371106..3371507 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0H3KN37
Locus tag BMULJ_RS15635 Protein ID WP_012467744.1
Coordinates 3371507..3371743 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMULJ_RS15620 3368427..3369569 + 1143 WP_006401424.1 alginate lyase family protein -
BMULJ_RS15625 3369596..3370984 + 1389 WP_012212497.1 L-serine ammonia-lyase -
BMULJ_RS15630 3371106..3371507 - 402 WP_012212496.1 type II toxin-antitoxin system VapC family toxin Toxin
BMULJ_RS15635 3371507..3371743 - 237 WP_012467744.1 AbrB family transcriptional regulator Antitoxin
BMULJ_RS15640 3371931..3373634 + 1704 WP_012212494.1 thiamine pyrophosphate-binding protein -
BMULJ_RS15645 3373631..3374728 + 1098 WP_012212493.1 hypothetical protein -
BMULJ_RS15650 3374856..3375887 - 1032 WP_012212492.1 helix-turn-helix domain-containing protein -
BMULJ_RS15655 3376050..3376592 - 543 WP_012467745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14930.10 Da        Isoelectric Point: 6.2246

>T22906 WP_012212496.1 NC_010804:c3371507-3371106 [Burkholderia multivorans ATCC 17616]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNHERDFAGYPGLRLENWLTG

Download         Length: 402 bp

>T22906 NC_010804:c3371507-3371106 [Burkholderia multivorans ATCC 17616]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGGTATGCGCCAATC
CGGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTTGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGCGAGGCGACGCGGGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCGGTATCGCT
CGACGTCGTGCTGGTGACCAACCACGAGCGTGATTTCGCGGGTTATCCGGGCTTGAGGCTCGAGAACTGGCTGACCGGCT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8784.90 Da        Isoelectric Point: 8.7077

>AT22906 WP_012467744.1 NC_010804:c3371743-3371507 [Burkholderia multivorans ATCC 17616]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAERKGG

Download         Length: 237 bp

>AT22906 NC_010804:c3371743-3371507 [Burkholderia multivorans ATCC 17616]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTGGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCCGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCAAGGGTGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KIE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KN37

References