Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2240214..2241112 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag LVJ73_RS10480 Protein ID WP_003410001.1
Coordinates 2240214..2240774 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag LVJ73_RS10485 Protein ID WP_003410003.1
Coordinates 2240771..2241112 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS10450 (LVJ73_10465) 2235383..2236036 - 654 WP_003409976.1 cutinase Cfp21 -
LVJ73_RS10455 (LVJ73_10470) 2236151..2236381 + 231 WP_003409980.1 DUF167 domain-containing protein -
LVJ73_RS10460 (LVJ73_10475) 2236466..2237377 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LVJ73_RS10465 (LVJ73_10480) 2237486..2238085 + 600 WP_003409989.1 L-lysine exporter -
LVJ73_RS10470 (LVJ73_10485) 2238501..2238929 + 429 WP_003409992.1 cellulose-binding protein -
LVJ73_RS10475 (LVJ73_10490) 2239155..2239694 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
LVJ73_RS10480 (LVJ73_10495) 2240214..2240774 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
LVJ73_RS10485 (LVJ73_10500) 2240771..2241112 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
LVJ73_RS10490 (LVJ73_10505) 2241198..2241455 + 258 WP_003410006.1 hypothetical protein -
LVJ73_RS10495 (LVJ73_10510) 2241356..2241691 - 336 WP_003410009.1 dehydrogenase -
LVJ73_RS10500 (LVJ73_10515) 2241780..2242124 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
LVJ73_RS10505 (LVJ73_10520) 2242118..2242366 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
LVJ73_RS10510 (LVJ73_10525) 2242466..2244781 - 2316 WP_003899120.1 cation transporter ATPase CptG -
LVJ73_RS10515 (LVJ73_10530) 2244778..2245050 - 273 WP_003410017.1 DUF1490 family protein -
LVJ73_RS10520 (LVJ73_10535) 2245103..2245459 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T229058 WP_003410001.1 NZ_CP089778:c2240774-2240214 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T229058 NZ_CP124375:56579-56854 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT229058 WP_003410003.1 NZ_CP089778:c2241112-2240771 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT229058 NZ_CP124375:56295-56579 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References