Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1947497..1948110 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag LVJ73_RS09105 Protein ID WP_003408465.1
Coordinates 1947497..1947886 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LVJ73_RS09110 Protein ID WP_003408469.1
Coordinates 1947883..1948110 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS09070 (LVJ73_09080) 1943126..1944040 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LVJ73_RS09075 (LVJ73_09085) 1944043..1944873 + 831 WP_003408448.1 cyclase family protein -
LVJ73_RS09080 (LVJ73_09090) 1944873..1945223 + 351 WP_003898986.1 cupin domain-containing protein -
LVJ73_RS09085 (LVJ73_09095) 1945276..1946094 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
LVJ73_RS09090 (LVJ73_09100) 1946108..1946887 + 780 WP_003408460.1 IclR family transcriptional regulator -
LVJ73_RS09100 (LVJ73_09110) 1947318..1947449 + 132 Protein_1795 IS3 family transposase -
LVJ73_RS09105 (LVJ73_09115) 1947497..1947886 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ73_RS09110 (LVJ73_09120) 1947883..1948110 - 228 WP_003408469.1 antitoxin Antitoxin
LVJ73_RS09115 (LVJ73_09125) 1948328..1949812 + 1485 WP_003408473.1 biotin carboxylase -
LVJ73_RS09120 (LVJ73_09130) 1949809..1951056 + 1248 WP_003408476.1 serine hydrolase -
LVJ73_RS09125 (LVJ73_09135) 1951099..1951518 - 420 WP_003408483.1 hypothetical protein -
LVJ73_RS09130 (LVJ73_09140) 1951508..1952217 - 710 Protein_1801 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T229052 WP_003408465.1 NZ_CP089778:c1947886-1947497 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T229052 NZ_CP124374:4244229-4244693 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT229052 WP_003408469.1 NZ_CP089778:c1948110-1947883 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT229052 NZ_CP124374:4243894-4244229 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References