Detailed information of TA system TA022905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2500164..2500864
• Replicon: chromosome
• Accession: NC_010804
• Organism: Burkholderia multivorans ATCC 17616

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: BMULJ_RS11580
• Protein ID: WP_044055262.1
• Coordinates: 2500164..2500541 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: BMULJ_RS11585
• Protein ID: WP_012212958.1
• Coordinates: 2500541..2500864 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BMULJ_RS11555	2495705..2496154	+	450	WP_006413500.1	VOC family protein	-
BMULJ_RS11560	2496258..2497808	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
BMULJ_RS11565	2497805..2498038	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
BMULJ_RS11570	2498235..2499152	-	918	WP_012212961.1	spermidine synthase	-
BMULJ_RS11575	2499380..2499634	+	255	WP_012212960.1	hypothetical protein	-
BMULJ_RS35160	2500003..2500191	-	189	WP_172641365.1	hypothetical protein	-
BMULJ_RS11580	2500164..2500541	+	378	WP_044055262.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BMULJ_RS11585	2500541..2500864	+	324	WP_012212958.1	helix-turn-helix domain-containing protein	Antitoxin
BMULJ_RS11590	2500887..2501378	-	492	WP_012467675.1	DNA-deoxyinosine glycosylase	-
BMULJ_RS11595	2501375..2501989	-	615	WP_012212956.1	chorismate lyase	-
BMULJ_RS11600	2501998..2503896	-	1899	WP_012212955.1	molecular chaperone HtpG	-
BMULJ_RS11605	2504056..2505516	-	1461	WP_012212954.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13703.75 Da
• Isoelectric Point: 9.7870

>T22905 WP_044055262.1 NC_010804:2500164-2500541 [Burkholderia multivorans ATCC 17616]
MGINSSMVPYTKPLYWLGSARRDLKAMPEAVQDTFGYALYLAQTRGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T22905 NC_010804:2500164-2500541 [Burkholderia multivorans ATCC 17616]
ATGGGTATAAATTCGTCGATGGTTCCATACACCAAACCGCTCTACTGGCTCGGCTCGGCACGCAGGGACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTCGGCTATGCGCTGTATCTGGCTCAGACGAGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGCTTCGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACGCCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGGGCCGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11842.78 Da
• Isoelectric Point: 8.0686

>AT22905 WP_012212958.1 NC_010804:2500541-2500864 [Burkholderia multivorans ATCC 17616]
MIEIERGSGNVYADLGMPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHTEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT22905 NC_010804:2500541-2500864 [Burkholderia multivorans ATCC 17616]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTGGGCATGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCGGCCAAGATCGCGGAGATCATCAAGACCCGCAAATGGACGCAGCAGCACGCGGCGCGGTTGCTCGGCATGA
CGCAACCGAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGCGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGACGCGATGTCCAGATCGTCGTAGGACCGGACCGTCATACGGAAGCCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA