Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1540158..1541208 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag LVJ73_RS07290 Protein ID WP_003407164.1
Coordinates 1540158..1540979 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag LVJ73_RS07295 Protein ID WP_003407167.1
Coordinates 1540972..1541208 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS07270 (LVJ73_07275) 1535716..1536378 - 663 WP_003407152.1 membrane protein -
LVJ73_RS07275 (LVJ73_07280) 1536375..1537160 - 786 WP_003407157.1 membrane protein -
LVJ73_RS07280 (LVJ73_07285) 1537451..1539412 - 1962 WP_003407159.1 sigma-F factor regulator -
LVJ73_RS07285 (LVJ73_07290) 1539551..1539937 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
LVJ73_RS07290 (LVJ73_07295) 1540158..1540979 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
LVJ73_RS07295 (LVJ73_07300) 1540972..1541208 + 237 WP_003407167.1 hypothetical protein Antitoxin
LVJ73_RS07300 (LVJ73_07305) 1541280..1542485 - 1206 WP_003898846.1 serine hydrolase domain-containing protein -
LVJ73_RS07305 (LVJ73_07310) 1542788..1543573 + 786 WP_003407180.1 lipoprotein LprF -
LVJ73_RS07310 (LVJ73_07315) 1543769..1545238 + 1470 WP_003900326.1 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T229048 WP_003407164.1 NZ_CP089778:1540158-1540979 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T229048 NZ_CP124374:c2990818-2990567 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT229048 WP_003407167.1 NZ_CP089778:1540972-1541208 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT229048 NZ_CP124374:c2990570-2990316 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References