Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 756997..757685 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag LVJ73_RS03500 Protein ID WP_003403386.1
Coordinates 756997..757434 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag LVJ73_RS03505 Protein ID WP_003911263.1
Coordinates 757431..757685 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS03470 (LVJ73_03465) 753248..754258 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
LVJ73_RS03475 (LVJ73_03470) 754646..755029 - 384 WP_003403365.1 ribonuclease VapC6 -
LVJ73_RS03480 (LVJ73_03475) 755124..755279 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
LVJ73_RS03485 (LVJ73_03480) 755355..756071 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
LVJ73_RS03490 (LVJ73_03485) 756347..756655 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
LVJ73_RS03495 (LVJ73_03490) 756642..756887 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
LVJ73_RS03500 (LVJ73_03495) 756997..757434 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ73_RS03505 (LVJ73_03500) 757431..757685 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
LVJ73_RS03510 (LVJ73_03505) 757799..760162 + 2364 WP_003898547.1 arylsulfatase AtsD -
LVJ73_RS03515 (LVJ73_03510) 760225..760551 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ73_RS03520 (LVJ73_03515) 760463..760801 + 339 WP_003403405.1 PIN domain-containing protein -
LVJ73_RS03525 (LVJ73_03520) 760798..760971 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T229039 WP_003403386.1 NZ_CP089778:c757434-756997 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T229039 NZ_CP124374:758185-758469 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT229039 WP_003911263.1 NZ_CP089778:c757685-757431 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT229039 NZ_CP124374:757949-758182 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References