Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704373..705016 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LVJ73_RS03205 Protein ID WP_003403187.1
Coordinates 704615..705016 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LVJ73_RS03200 Protein ID WP_003403184.1
Coordinates 704373..704618 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS03165 (LVJ73_03160) 699653..700183 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ73_RS03170 (LVJ73_03165) 700167..700862 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ73_RS03175 (LVJ73_03170) 700985..701296 + 312 WP_003403164.1 hypothetical protein -
LVJ73_RS03180 (LVJ73_03175) 701368..702318 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ73_RS03185 (LVJ73_03180) 702559..703143 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ73_RS03190 (LVJ73_03185) 703145..703855 + 711 Protein_632 IS607 family element RNA-guided endonuclease TnpB -
LVJ73_RS03195 (LVJ73_03190) 703858..704328 + 471 WP_003898523.1 hypothetical protein -
LVJ73_RS03200 (LVJ73_03195) 704373..704618 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ73_RS03205 (LVJ73_03200) 704615..705016 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ73_RS03210 (LVJ73_03205) 705007..705186 + 180 Protein_636 hypothetical protein -
LVJ73_RS03215 (LVJ73_03210) 705604..705801 - 198 WP_003403191.1 hypothetical protein -
LVJ73_RS03220 (LVJ73_03215) 705881..707038 - 1158 WP_003898524.1 hypothetical protein -
LVJ73_RS03225 (LVJ73_03220) 707090..707311 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ73_RS03230 (LVJ73_03225) 707453..708058 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T229032 WP_003403187.1 NZ_CP089778:704615-705016 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T229032 NZ_CP124373:c77433-77284 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT229032 WP_003403184.1 NZ_CP089778:704373-704618 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT229032 NZ_CP124373:77477-77538 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References