Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 363926..364569 Replicon chromosome
Accession NZ_CP089778
Organism Mycobacterium tuberculosis strain I0003758-5

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ73_RS01590 Protein ID WP_003401566.1
Coordinates 364144..364569 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ73_RS01585 Protein ID WP_003401563.1
Coordinates 363926..364147 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ73_RS01560 (LVJ73_01560) 359054..359857 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ73_RS01565 (LVJ73_01565) 359867..361264 - 1398 WP_003401544.1 sulfatase -
LVJ73_RS01570 (LVJ73_01570) 361443..363209 + 1767 WP_070889677.1 PE family protein -
LVJ73_RS01575 (LVJ73_01575) 363352..363579 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
LVJ73_RS01580 (LVJ73_01580) 363576..363878 + 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ73_RS01585 (LVJ73_01585) 363926..364147 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ73_RS01590 (LVJ73_01590) 364144..364569 + 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ73_RS01595 (LVJ73_01595) 364705..365337 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ73_RS01600 (LVJ73_01600) 365334..366242 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ73_RS01605 (LVJ73_01605) 366250..366840 - 591 WP_229298012.1 hypothetical protein -
LVJ73_RS01610 (LVJ73_01610) 366833..366883 - 51 Protein_318 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T229026 WP_003401566.1 NZ_CP089778:364144-364569 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T229026 NZ_CP124372:3715379-3715906 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT229026 WP_003401563.1 NZ_CP089778:363926-364147 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT229026 NZ_CP124372:3715106-3715372 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References