Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3791022..3791551 | Replicon | chromosome |
| Accession | NZ_CP089777 | ||
| Organism | Mycobacterium tuberculosis strain I0003270-1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | LVJ72_RS17880 | Protein ID | WP_003417760.1 |
| Coordinates | 3791294..3791551 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | LVJ72_RS17875 | Protein ID | WP_003417757.1 |
| Coordinates | 3791022..3791297 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ72_RS17840 (LVJ72_17845) | 3787595..3788284 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| LVJ72_RS17845 (LVJ72_17850) | 3788471..3788842 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| LVJ72_RS17850 (LVJ72_17855) | 3788740..3788958 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| LVJ72_RS17855 (LVJ72_17860) | 3788985..3789245 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| LVJ72_RS17860 (LVJ72_17865) | 3789360..3789749 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| LVJ72_RS17865 (LVJ72_17870) | 3789763..3790056 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| LVJ72_RS17870 (LVJ72_17875) | 3790053..3790898 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| LVJ72_RS17875 (LVJ72_17880) | 3791022..3791297 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| LVJ72_RS17880 (LVJ72_17885) | 3791294..3791551 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| LVJ72_RS17885 (LVJ72_17890) | 3791593..3792783 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| LVJ72_RS17890 (LVJ72_17895) | 3792900..3793268 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| LVJ72_RS17895 (LVJ72_17900) | 3793265..3793816 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| LVJ72_RS17900 (LVJ72_17905) | 3793823..3794404 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| LVJ72_RS17905 (LVJ72_17910) | 3794385..3794753 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| LVJ72_RS17910 (LVJ72_17915) | 3794731..3795123 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T229020 WP_003417760.1 NZ_CP089777:3791294-3791551 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T229020 NZ_CP124372:c2607261-2606911 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT229020 WP_003417757.1 NZ_CP089777:3791022-3791297 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT229020 NZ_CP124372:c2607506-2607255 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|