Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3725438..3726112 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ72_RS17660 Protein ID WP_003417282.1
Coordinates 3725438..3725866 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ72_RS17665 Protein ID WP_003417286.1
Coordinates 3725870..3726112 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS17635 (LVJ72_17640) 3721260..3721661 - 402 WP_003417264.1 cytidine deaminase -
LVJ72_RS17640 (LVJ72_17645) 3721898..3722236 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ72_RS17645 (LVJ72_17650) 3722233..3722667 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ72_RS17650 (LVJ72_17655) 3722796..3724568 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ72_RS17655 (LVJ72_17660) 3724568..3725359 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ72_RS17660 (LVJ72_17665) 3725438..3725866 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ72_RS17665 (LVJ72_17670) 3725870..3726112 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ72_RS17670 (LVJ72_17675) 3726234..3726848 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ72_RS17675 (LVJ72_17680) 3726845..3727510 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LVJ72_RS17680 (LVJ72_17685) 3727511..3728044 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ72_RS17685 (LVJ72_17690) 3728041..3728415 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LVJ72_RS17690 (LVJ72_17695) 3728512..3729648 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T229019 WP_003417282.1 NZ_CP089777:c3725866-3725438 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T229019 NZ_CP124372:c2510235-2509858 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT229019 WP_003417286.1 NZ_CP089777:c3726112-3725870 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT229019 NZ_CP124372:c2510693-2510325 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References