Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3151138..3152912 | Replicon | chromosome |
| Accession | NZ_CP089777 | ||
| Organism | Mycobacterium tuberculosis strain I0003270-1 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | LVJ72_RS15035 | Protein ID | WP_003414409.1 |
| Coordinates | 3151138..3152022 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | LVJ72_RS15040 | Protein ID | WP_003414414.1 |
| Coordinates | 3152025..3152912 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ72_RS15015 (LVJ72_15020) | 3146393..3146767 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| LVJ72_RS15020 (LVJ72_15025) | 3146764..3149202 | - | 2439 | WP_003900580.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| LVJ72_RS15025 (LVJ72_15030) | 3149199..3149987 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| LVJ72_RS15030 (LVJ72_15035) | 3150321..3150866 | - | 546 | WP_003913758.1 | DUF1802 family protein | - |
| LVJ72_RS15035 (LVJ72_15040) | 3151138..3152022 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LVJ72_RS15040 (LVJ72_15045) | 3152025..3152912 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| LVJ72_RS15045 (LVJ72_15050) | 3153217..3153762 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
| LVJ72_RS15050 (LVJ72_15055) | 3153759..3154028 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| LVJ72_RS15055 (LVJ72_15060) | 3154049..3154441 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ72_RS15060 (LVJ72_15065) | 3154438..3154653 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ72_RS15065 (LVJ72_15070) | 3154700..3155449 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| LVJ72_RS15070 (LVJ72_15075) | 3155528..3156610 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T229014 WP_003414409.1 NZ_CP089777:c3152022-3151138 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T229014 NZ_CP124372:c1836246-1835944 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT229014 WP_003414414.1 NZ_CP089777:c3152912-3152025 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT229014 NZ_CP124372:c1835908-1835567 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|