Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3126118..3126646 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LVJ72_RS14905 Protein ID WP_044108447.1
Coordinates 3126118..3126432 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag LVJ72_RS14910 Protein ID WP_003901465.1
Coordinates 3126416..3126646 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS14885 (LVJ72_14890) 3121528..3123216 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
LVJ72_RS14890 (LVJ72_14895) 3123220..3123546 - 327 WP_003414157.1 hypothetical protein -
LVJ72_RS14895 (LVJ72_14900) 3123719..3124306 + 588 WP_003914429.1 DUF3558 family protein -
LVJ72_RS14900 (LVJ72_14905) 3124325..3125974 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
LVJ72_RS14905 (LVJ72_14910) 3126118..3126432 - 315 WP_044108447.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LVJ72_RS14910 (LVJ72_14915) 3126416..3126646 - 231 WP_003901465.1 type II toxin-antitoxin system antitoxin MazE9 Antitoxin
LVJ72_RS14915 (LVJ72_14920) 3126689..3127732 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
LVJ72_RS14920 (LVJ72_14925) 3127731..3128198 + 468 WP_003414177.1 DUF1778 domain-containing protein -
LVJ72_RS14925 (LVJ72_14930) 3128374..3128628 - 255 WP_003917684.1 hypothetical protein -
LVJ72_RS14930 (LVJ72_14935) 3128776..3129180 + 405 WP_009938577.1 hypothetical protein -
LVJ72_RS14935 (LVJ72_14940) 3129177..3129368 + 192 WP_003414184.1 hypothetical protein -
LVJ72_RS14940 (LVJ72_14945) 3129585..3129845 + 261 Protein_2949 transposase -
LVJ72_RS14945 (LVJ72_14950) 3130955..3131212 + 258 WP_003899489.1 hypothetical protein -
LVJ72_RS14950 (LVJ72_14955) 3131317..3131628 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11195.82 Da        Isoelectric Point: 10.7779

>T229013 WP_044108447.1 NZ_CP089777:c3126432-3126118 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELA

Download         Length: 315 bp

>T229013 NZ_CP124372:984654-984761 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT229013 WP_003901465.1 NZ_CP089777:c3126646-3126416 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT229013 NZ_CP124372:c984597-984542 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References