Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2825303..2825955 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag LVJ72_RS13290 Protein ID WP_003412752.1
Coordinates 2825530..2825955 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag LVJ72_RS13285 Protein ID WP_003412749.1
Coordinates 2825303..2825524 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS13270 (LVJ72_13270) 2823543..2823749 - 207 WP_003899347.1 hypothetical protein -
LVJ72_RS13275 (LVJ72_13275) 2823885..2824508 + 624 WP_003900858.1 TIGR00725 family protein -
LVJ72_RS13280 (LVJ72_13280) 2824498..2825250 + 753 WP_003900859.1 hypothetical protein -
LVJ72_RS13285 (LVJ72_13285) 2825303..2825524 + 222 WP_003412749.1 antitoxin Antitoxin
LVJ72_RS13290 (LVJ72_13290) 2825530..2825955 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ72_RS13295 (LVJ72_13295) 2825978..2827159 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
LVJ72_RS13300 (LVJ72_13300) 2827156..2828202 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
LVJ72_RS13305 (LVJ72_13305) 2828213..2829316 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
LVJ72_RS13310 (LVJ72_13310) 2829575..2830396 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
LVJ72_RS13315 (LVJ72_13315) 2830393..2830950 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T229004 WP_003412752.1 NZ_CP089777:2825530-2825955 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T229004 NZ_CP124367:c5101709-5101602 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT229004 WP_003412749.1 NZ_CP089777:2825303-2825524 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT229004 NZ_CP124367:5101757-5101823 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References