Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2420748..2421277 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag LVJ72_RS11365 Protein ID WP_003411124.1
Coordinates 2420748..2421065 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag LVJ72_RS11370 Protein ID WP_003411127.1
Coordinates 2421062..2421277 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS11335 (LVJ72_11345) 2415885..2416961 + 1077 WP_003411110.1 hypothetical protein -
LVJ72_RS11340 (LVJ72_11350) 2416958..2417239 + 282 WP_003411112.1 DUF5703 family protein -
LVJ72_RS11345 (LVJ72_11355) 2417275..2418348 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
LVJ72_RS11350 (LVJ72_11360) 2418353..2418883 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
LVJ72_RS11355 (LVJ72_11365) 2418931..2420277 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
LVJ72_RS11365 (LVJ72_11375) 2420748..2421065 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ72_RS11370 (LVJ72_11380) 2421062..2421277 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
LVJ72_RS11375 (LVJ72_11385) 2421532..2422590 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
LVJ72_RS11380 (LVJ72_11390) 2422720..2423076 - 357 WP_003411130.1 hypothetical protein -
LVJ72_RS11385 (LVJ72_11395) 2423171..2423953 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
LVJ72_RS11390 (LVJ72_11400) 2424221..2424511 - 291 WP_003900476.1 YggT family protein -
LVJ72_RS11395 (LVJ72_11405) 2424673..2425329 - 657 WP_003411133.1 cell division protein SepF -
LVJ72_RS11400 (LVJ72_11410) 2425395..2426171 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T229003 WP_003411124.1 NZ_CP089777:c2421065-2420748 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T229003 NZ_CP124367:4252652-4252954 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT229003 WP_003411127.1 NZ_CP089777:c2421277-2421062 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT229003 NZ_CP124367:4252990-4253331 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References