Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2384000..2384695 Replicon chromosome
Accession NZ_CP089777
Organism Mycobacterium tuberculosis strain I0003270-1

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ72_RS11155 Protein ID WP_003410811.1
Coordinates 2384000..2384434 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ72_RS11160 Protein ID WP_003410814.1
Coordinates 2384441..2384695 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ72_RS11145 (LVJ72_11155) 2380154..2383195 + 3042 WP_031705357.1 DEAD/DEAH box helicase -
LVJ72_RS11150 (LVJ72_11160) 2383188..2384021 + 834 WP_003899172.1 SWIM zinc finger family protein -
LVJ72_RS11155 (LVJ72_11165) 2384000..2384434 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ72_RS11160 (LVJ72_11170) 2384441..2384695 - 255 WP_003410814.1 antitoxin Antitoxin
LVJ72_RS11165 (LVJ72_11175) 2384711..2384968 - 258 WP_003410816.1 hypothetical protein -
LVJ72_RS11170 (LVJ72_11180) 2385915..2386211 + 297 WP_003410820.1 PE family protein -
LVJ72_RS11175 (LVJ72_11185) 2386267..2386998 + 732 WP_003900467.1 PPE family protein -
LVJ72_RS11180 (LVJ72_11190) 2387538..2388284 - 747 WP_003906749.1 proteasome subunit alpha -
LVJ72_RS11185 (LVJ72_11195) 2388281..2389156 - 876 WP_003411023.1 proteasome subunit beta -
LVJ72_RS11190 (LVJ72_11200) 2389153..2389347 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T229002 WP_003410811.1 NZ_CP089777:c2384434-2384000 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T229002 NZ_CP124367:c4223698-4223480 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT229002 WP_003410814.1 NZ_CP089777:c2384695-2384441 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT229002 NZ_CP124367:c4224098-4223724 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References